Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland.
Department of Biotechnology, Medical University of Bialystok, Kilinskiego 1, 15-089 Bialystok, Poland.
Nutrients. 2021 May 13;13(5):1649. doi: 10.3390/nu13051649.
This review answers the question of why selenium is such an important trace element in the human diet. Daily dietary intake of selenium and its content in various food products is discussed in this paper, as well as the effects of its deficiency and excess in the body. Moreover, the biological activity of selenium, which it performs mainly through selenoproteins, is discussed. These specific proteins are responsible for thyroid hormone management, fertility, the aging process, and immunity, but their key role is to maintain a redox balance in cells. Furthermore, taking into account world news and the current SARS-CoV-2 virus pandemic, the impact of selenium on the course of COVID-19 is also discussed. Another worldwide problem is the number of new cancer cases and cancer-related mortality. Thus, the last part of the article discusses the impact of selenium on cancer risk based on clinical trials (including NPC and SELECT), systematic reviews, and meta-analyses. Additionally, this review discusses the possible mechanisms of selenium action that prevent cancer development.
本文回答了为什么硒是人类饮食中如此重要的微量元素这一问题。本文讨论了每日硒的膳食摄入量及其在各种食品中的含量，以及体内硒缺乏和过量的影响。此外，还讨论了硒的生物活性，它主要通过硒蛋白发挥作用。这些特定的蛋白质负责甲状腺激素的管理、生育能力、衰老过程和免疫力，但它们的关键作用是维持细胞内的氧化还原平衡。此外，考虑到世界新闻和当前 SARS-CoV-2 病毒大流行，还讨论了硒对 COVID-19 病程的影响。另一个全球性问题是新癌症病例和癌症相关死亡率的数量。因此，文章的最后一部分讨论了基于临床试验（包括 NPC 和 SELECT）、系统评价和荟萃分析的硒对癌症风险的影响。此外，本文还讨论了硒预防癌症发展的可能作用机制。
