Mason Ashley E, Kasl Patrick, Hartogensis Wendy, Natale Joseph L, Dilchert Stephan, Dasgupta Subhasis, Purawat Shweta, Chowdhary Anoushka, Anglo Claudine, Veasna Danou, Pandya Leena S, Fox Lindsey M, Puldon Karena Y, Prather Jenifer G, Gupta Amarnath, Altintas Ilkay, Smarr Benjamin L, Hecht Frederick M
Osher Center for Integrative Health, University of California San Francisco, San Francisco, CA 94115, USA.
Halıcıoğlu Data Science Institute, University of California San Diego, San Diego, CA 92093, USA.
Vaccines (Basel). 2022 Feb 9;10(2):264. doi: 10.3390/vaccines10020264.
There is significant variability in neutralizing antibody responses (which correlate with immune protection) after COVID-19 vaccination, but only limited information is available about predictors of these responses. We investigated whether device-generated summaries of physiological metrics collected by a wearable device correlated with post-vaccination levels of antibodies to the SARS-CoV-2 receptor-binding domain (RBD), the target of neutralizing antibodies generated by existing COVID-19 vaccines. One thousand, one hundred and seventy-nine participants wore an off-the-shelf wearable device (Oura Ring), reported dates of COVID-19 vaccinations, and completed testing for antibodies to the SARS-CoV-2 RBD during the U.S. COVID-19 vaccination rollout. We found that on the night immediately following the second mRNA injection (Moderna-NIAID and Pfizer-BioNTech) increases in dermal temperature deviation and resting heart rate, and decreases in heart rate variability (a measure of sympathetic nervous system activation) and deep sleep were each statistically significantly correlated with greater RBD antibody responses. These associations were stronger in models using metrics adjusted for the pre-vaccination baseline period. Greater temperature deviation emerged as the strongest independent predictor of greater RBD antibody responses in multivariable models. In contrast to data on certain other vaccines, we did not find clear associations between increased sleep surrounding vaccination and antibody responses.
新冠病毒疫苗接种后，中和抗体反应（与免疫保护相关）存在显著差异，但关于这些反应的预测因素的信息有限。我们调查了可穿戴设备收集的生理指标的设备生成摘要是否与接种疫苗后针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）受体结合域（RBD）的抗体水平相关，RBD是现有新冠病毒疫苗产生的中和抗体的靶点。1179名参与者佩戴了一款现成的可穿戴设备（奥ura戒指），报告了新冠病毒疫苗接种日期，并在美国新冠病毒疫苗推广期间完成了针对SARS-CoV-2 RBD抗体的检测。我们发现，在第二次mRNA注射（Moderna-NIAID和辉瑞-BioNTech）后的当晚，皮肤温度偏差和静息心率增加，心率变异性（交感神经系统激活的一种测量指标）和深度睡眠减少，这些均与更高的RBD抗体反应在统计学上显著相关。在使用针对接种疫苗前基线期进行调整的指标的模型中，这些关联更强。在多变量模型中，更大的温度偏差成为更高RBD抗体反应的最强独立预测因素。与某些其他疫苗的数据不同，我们没有发现接种疫苗前后睡眠时间增加与抗体反应之间存在明确关联。
