Khalil Lana, Leary Maranda, Rouphael Nadine, Ofotokun Ighovwerha, Rebolledo Paulina A, Wiley Zanthia
The Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, 500 Irvin Court Suite 200, Decatur, GA 30030, USA.
Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30030, USA.
Vaccines (Basel). 2022 Feb 14;10(2):290. doi: 10.3390/vaccines10020290.
Evidence shows that White and non-Hispanic individuals are overrepresented in clinical trials. The development of new vaccines and drugs, however, necessitates that clinical research trials include representative participants, particularly in light of evidence showing that underrepresented minorities may have a different response to certain medications and vaccines. Racial and ethnic disparities among clinical trials are multilayered and complex, and this requires action. The results of this study indicate that significant racial and ethnic disparities consistently exist among the most recent early SARS-CoV-2 vaccine clinical trials as compared to the pandemic H1N1 vaccine clinical trials of 2009. New strategies, policies, training programs, and reforms are required to address these disparities among clinical trials.
有证据表明，白人和非西班牙裔个体在临床试验中的占比过高。然而，新疫苗和药物的研发需要临床研究试验纳入具有代表性的参与者，尤其是鉴于有证据表明，代表性不足的少数群体对某些药物和疫苗可能有不同反应。临床试验中的种族和族裔差异是多层面且复杂的，这需要采取行动。这项研究的结果表明，与2009年甲型H1N1流感大流行疫苗临床试验相比，最近的早期SARS-CoV-2疫苗临床试验中始终存在显著的种族和族裔差异。需要新的策略、政策、培训计划和改革来解决临床试验中的这些差异。
