Vaccine Development and Evaluation Centre (VDEC), United Kingdom Health Security Agency, Salisbury, UK.
Faculty of Veterinary Medicine, Vietnam National University of Agriculture, Hanoi, Vietnam.
Virulence. 2024 Dec;15(1):2375550. doi: 10.1080/21505594.2024.2375550. Epub 2024 Jul 7.
African swine fever (ASF) is a devastating disease with a high impact on the pork industry worldwide. ASF virus (ASFV) is a very complex pathogen, the sole member of the family , which induces a state of immune suppression in the host through infection of myeloid cells and apoptosis of lymphocytes. Moreover, haemorrhages are the other main pathogenic effect of ASFV infection in pigs, related to the infection of endothelial cells, as well as the activation and structural changes of this cell population by proinflammatory cytokine upregulation within bystander monocytes and macrophages. There are still many gaps in the knowledge of the role of proteins produced by the ASFV, which is related to the difficulty in producing a safe and effective vaccine to combat the disease, although few candidates have been approved for use in Southeast Asia in the past couple of years.
非洲猪瘟（ASF）是一种具有全球破坏性的疾病，对养猪业影响巨大。非洲猪瘟病毒（ASFV）是一种非常复杂的病原体，是该科唯一的成员，通过感染髓样细胞和淋巴细胞凋亡，在宿主中诱导免疫抑制状态。此外，ASF 感染在猪中的另一个主要致病效应是出血，这与内皮细胞的感染有关，以及通过旁分泌单核细胞和巨噬细胞中促炎细胞因子的上调，导致该细胞群体的激活和结构改变。由于生产安全有效的疫苗来对抗这种疾病具有难度，因此人们对 ASFV 产生的蛋白质的作用仍然知之甚少，尽管在过去几年中，东南亚已经批准了少数几种候选疫苗用于使用。
