Child and Adolescent Neurology and Psychiatric Section, Department of Clinical and Experimental Medicine, Catania University, 95124 Catania, Italy.
Department of Cognitive Sciences, Psychology, Education and Cultural Studies, University of Messina, 98121 Messina, Italy.
Nutrients. 2022 Feb 18;14(4):852. doi: 10.3390/nu14040852.
Tourette syndrome (TS) is a neurodevelopmental disorder characterized by tics and co-occurring disorders. It has been suggested that anxiety occurs in 2-45% patients affected by Tourette syndrome. Despite dietary and nutritional factors have been found to affect a range of neurological conditions, no more studies have investigated the relationship between nutritional supplements and tics.
To evaluate the effectiveness of supplementation of both L-Theanine and Vitamin B6 in reducing tics and co-occurring disorders in a sample of youth with chronic tic disorder (CTD) or Tourette syndrome with anxiety symptoms.
A open-label trial. Patients affected by Tourette syndrome were randomized to receive nutritional supplements based on L-Theanine and vitamin B6, or psychoeducation (PE).
34 children (30 boys and 4 girls) aged between 4 and 17 years affected by Tourette syndrome or chronic tic disorder, associated with anxiety symptoms.
Patients in both groups showed a reduction in the severity of tic and anxiety symptoms. Supplementation with L-Theanine and vitamin B6 was significantly more effective than psychoeducation in reducing tics and co-occurring disorders, as measured by neuropsychological findings.
Supplementation of both L-Theanine and Vitamin B6 may help in the treatment of tic disorders associated with anxious symptoms. Between-group differences in clinician-rated severity did reach statistical significance only for tics. Despite this finding, further placebo-controlled trials are needed.
抽动秽语综合征（TS）是一种神经发育障碍，其特征为抽动和共病障碍。据报道，2%-45%的抽动秽语综合征患者存在焦虑。尽管饮食和营养因素已被发现影响一系列神经疾病，但尚未有更多研究调查营养补充剂与抽动之间的关系。
评估补充 L-茶氨酸和维生素 B6 对减轻伴有焦虑症状的慢性抽动障碍（CTD）或抽动秽语综合征患者抽动和共病障碍的有效性。
开放性试验。患有抽动秽语综合征的患者被随机分配接受基于 L-茶氨酸和维生素 B6 的营养补充剂或心理教育（PE）。
34 名年龄在 4 至 17 岁之间的儿童（30 名男孩和 4 名女孩），患有抽动秽语综合征或慢性抽动障碍，并伴有焦虑症状。
两组患者的抽动和焦虑症状严重程度均有所减轻。与心理教育相比，补充 L-茶氨酸和维生素 B6 在减少抽动和共病障碍方面更为有效，这可以通过神经心理学发现来衡量。
补充 L-茶氨酸和维生素 B6 可能有助于治疗伴有焦虑症状的抽动障碍。尽管组间差异在临床医生评定的严重程度上仅达到统计学意义，但仅针对抽动症状。尽管有此发现，但仍需要进行安慰剂对照试验。
