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高脂饮食诱导肥胖小鼠中金桔（Hort. ex Tanaka）叶中富含多甲氧基黄酮的部分的抗肥胖作用。

Anti-Obesity Effects of Polymethoxyflavone-Rich Fraction from Jinkyool ( Hort. ex Tanaka) Leaf on Obese Mice Induced by High-Fat Diet.

机构信息

Department of Biology, Jeju National University, Jeju 63243, Korea.

Biotech Regional Innovation Center, Jeju Nation University, Jeju 63423, Korea.

出版信息

Nutrients. 2022 Feb 18;14(4):865. doi: 10.3390/nu14040865.

DOI:10.3390/nu14040865
PMID:35215514
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8878017/
Abstract

Polymethoxyflavones (PMFs) are flavonoids exclusively found in certain citrus fruits and have been reported to be beneficial to human health. Most studies have been conducted with PMFs isolated from citrus peels, while there is no study on PMFs isolated from leaves. In this study, we prepared a PMF-rich fraction (PRF) from the leaves of Hort ex. Tanaka (Jinkyool) and investigated whether the PRF could improve metabolic decline in obese mice induced by a high-fat diet (HFD) for 5 weeks. The HFD-induced obese mice were assigned into HFD, OR (HFD + orlistat at 15.6 mg/kg of body weight/day), and PRF (HFD + 50, 100, and 200 mg/kg of body weight/day) groups. Orlistat and PRF were orally administered for 5 weeks. At the end of the experiment, the serum biochemical parameters, histology, and gene expression profiles in the tissues of each group were analyzed. The body weight gain of the obese mice was significantly reduced after orlistat and PRF administration for 5 weeks. PRF effectively improved HFD-induced insulin resistance and dyslipidemia. Histological analysis in the liver demonstrated that PRF decreased adipocyte size and potentially improved the liver function, as it inhibited the incidence of fatty liver. PRF activated AMP-activated protein kinase (AMPK), acetyl-CoA carboxylase (ACC), and hormone-sensitive lipase (HSL) in HFD-induced obese mice. Moreover, liver transcriptome analysis revealed that PRF administration enriched genes mainly related to fatty-acid metabolism and immune responses. Overall, these results suggest that the PRF exerted an anti-obesity effect via the modulation of lipid metabolism.

摘要

多甲氧基黄酮（PMFs）是仅存在于某些柑橘类水果中的类黄酮，已被报道对人类健康有益。大多数研究都是用从柑橘皮中分离出的 PMFs 进行的，而没有研究过从叶子中分离出的 PMFs。在这项研究中，我们从 Hort ex. Tanaka（Jinkyool）的叶子中制备了富含 PMFs 的馏分（PRF），并研究了 PRF 是否可以改善高脂肪饮食（HFD）诱导的肥胖小鼠 5 周后的代谢下降。将 HFD 诱导的肥胖小鼠分为 HFD、OR（HFD+每天 15.6 毫克/千克体重的奥利司他）和 PRF（HFD+50、100 和 200 毫克/千克体重/天）组。奥利司他和 PRF 经口给药 5 周。实验结束时，分析每组血清生化参数、组织学和基因表达谱。奥利司他和 PRF 给药 5 周后，肥胖小鼠的体重增加明显减少。PRF 有效改善了 HFD 诱导的胰岛素抵抗和血脂异常。肝脏组织学分析表明，PRF 减少了脂肪细胞的大小，并可能改善了肝功能，因为它抑制了脂肪肝的发生。PRF 激活了 AMP 激活的蛋白激酶（AMPK）、乙酰辅酶 A 羧化酶（ACC）和激素敏感脂肪酶（HSL）在 HFD 诱导的肥胖小鼠中。此外，肝脏转录组分析表明，PRF 给药使主要与脂肪酸代谢和免疫反应相关的基因丰富。总的来说，这些结果表明 PRF 通过调节脂质代谢发挥了抗肥胖作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/91108d31773d/nutrients-14-00865-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/34569e989fbf/nutrients-14-00865-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/17e6b227f88a/nutrients-14-00865-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/82d782836240/nutrients-14-00865-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/945f6bde838d/nutrients-14-00865-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/cd9395f029a9/nutrients-14-00865-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/112a852a3078/nutrients-14-00865-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/91108d31773d/nutrients-14-00865-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/34569e989fbf/nutrients-14-00865-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/17e6b227f88a/nutrients-14-00865-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/82d782836240/nutrients-14-00865-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/945f6bde838d/nutrients-14-00865-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/cd9395f029a9/nutrients-14-00865-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/112a852a3078/nutrients-14-00865-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3ba7/8878017/91108d31773d/nutrients-14-00865-g007.jpg

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