Maladies Infectieuses et Vecteurs: Écologie, Génétique, Évolution et Contrôle (MIVEGEC), Agropolis University Montpellier, Centre National de la Recherche Scientifique (CNRS), Institut de Recherche Pour le Développement (IRD), 34394 Montpellier, France.
Associated Medical Sciences (AMS)-PHPT Research Collaboration, Chiang Mai 50200, Thailand.
Viruses. 2021 Jul 22;13(8):1423. doi: 10.3390/v13081423.
Data about Zika virus infection and adverse pregnancy outcomes in Southeast Asia are scarce. We conducted an unmatched case-control study of Zika virus (ZIKV) serology in pregnant women enrolled in human immunodeficiency virus (HIV) or hepatitis B virus (HBV) perinatal prevention trials between 1997 and 2015 in Thailand. Case and control groups included women with and without adverse pregnancy outcomes. Plasma samples collected during the last trimester of pregnancy were tested for ZIKV IgG/IgM and Dengue IgG/IgM (Euroimmun, AG, Germany). Case newborn plasma samples were tested for ZIKV IgM and ZIKV RNA (Viasure, Spain). The case group included women with stillbirth ( = 22) or whose infants had microcephaly ( = 4), a head circumference below the first percentile ( = 14), neurological disorders ( = 36), or had died within 10 days after birth ( = 11). No women in the case group were positive for ZIKV IgM, and none of their live-born neonates were positive for ZIKV IgM or ZIKV RNA. The overall ZIKV IgG prevalence was 29%, 24% in the case and 34% in the control groups (Fisher's exact test; = 0.13), while the dengue IgG seroprevalence was 90%. Neither neonatal ZIKV infections nor ZIKV-related adverse pregnancy outcomes were observed in these women with HIV and/or HBV during the 18-year study period.
有关寨卡病毒感染和东南亚不良妊娠结局的数据很少。我们对 1997 年至 2015 年间在泰国参加人类免疫缺陷病毒（HIV）或乙型肝炎病毒（HBV）围产期预防试验的孕妇进行了寨卡病毒（ZIKV）血清学的非匹配病例对照研究。病例组和对照组包括有和无不良妊娠结局的孕妇。在妊娠最后三个月采集的血浆样本用于检测 ZIKV IgG/IgM 和登革热 IgG/IgM（Euroimmun，AG，德国）。病例新生儿血浆样本用于检测 ZIKV IgM 和 ZIKV RNA（Viasure，西班牙）。病例组包括死胎（=22 例）或其婴儿小头畸形（=4 例）、头围低于第一百分位数（=14 例）、神经障碍（=36 例）或出生后 10 天内死亡（=11 例）的妇女。病例组中没有妇女 ZIKV IgM 阳性，其活产新生儿也没有 ZIKV IgM 或 ZIKV RNA 阳性。总的 ZIKV IgG 阳性率为 29%，病例组为 24%，对照组为 34%（Fisher 精确检验；=0.13），而登革热 IgG 血清阳性率为 90%。在这项为期 18 年的研究中，这些感染 HIV 和/或 HBV 的妇女均未观察到新生儿 ZIKV 感染或 ZIKV 相关不良妊娠结局。
