Dept of Pharmacognosy, Sri Ramachandra Faculty of Pharmacy, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, 600116, India.
Dept of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Mysuru, Karnataka, 570015, India.
BMC Complement Med Ther. 2022 Feb 25;22(1):50. doi: 10.1186/s12906-021-03497-7.
Pain and inflammation are associatory events in cancer, diabetes, cardiovascular diseases, arthritis and other chronic diseases. Corticosteroids, non-steroidal anti-inflammatory drugs exert potential side effects on long term use. This study was aimed to investigate the acute oral toxicity, anti-inflammatory and analgesic activities of leaf and bark extracts of Albizia procera in experimental animal models.
Ethyl acetate, ethanol, and hydroalcoholic extracts of Albizia procera (leaf and bark) were subjected for acute oral toxicity, anti-inflammatory and analgesic screening. Carrageenan and cotton pellet granuloma models were used to assess acute and chronic anti-inflammatory effects, respectively. Intraplanar formalin test was used to assess the analgesic activity.
All the extracts of Albizia procera were found to be well-tolerated up to 2000 mg/kg in female rats. Ethanolic leaf (ETLE) and bark (ETBE) of Albizia procera showed anti-inflammatory actions. But, only ETBE produced significant protection in chronic inflammation and analgesic activity.
In summary, Albizia procera possess significant anti-inflammatory and analgesic properties. This study adds evidence on the traditional use of Albizia procera plant for treating painful inflammatory disorders.
疼痛和炎症是癌症、糖尿病、心血管疾病、关节炎和其他慢性疾病的关联事件。皮质类固醇和非甾体抗炎药长期使用会产生潜在的副作用。本研究旨在研究非洲轻木叶和树皮提取物在实验动物模型中的急性口服毒性、抗炎和镇痛活性。
对非洲轻木（叶和树皮）的乙酸乙酯、乙醇和水醇提取物进行急性口服毒性、抗炎和镇痛筛选。角叉菜胶和棉粒肉芽肿模型分别用于评估急性和慢性抗炎作用。平面内甲醛试验用于评估镇痛活性。
所有非洲轻木提取物在雌性大鼠中高达 2000mg/kg 时均耐受良好。非洲轻木的乙醇叶（ETLE）和树皮（ETBE）均具有抗炎作用。但只有 ETBE 对慢性炎症和镇痛活性有显著的保护作用。
总之，非洲轻木具有显著的抗炎和镇痛特性。本研究为非洲轻木植物用于治疗疼痛性炎症性疾病的传统用途提供了证据。
