Dibo Marcos, Ventimiglia María Silvia, Valeff Natalin, Serradell María de Los Ángeles, Jensen Federico
Center for Pharmacological and Botanical Studies (CEFYBO-UBA-CONICET), Medical Faculty, Buenos Aires University, Buenos Aires, Argentina.
Cátedra de Microbiología, Departamento de Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Argentina.
J Reprod Immunol. 2022 Mar;150:103493. doi: 10.1016/j.jri.2022.103493. Epub 2022 Feb 10.
Probiotics can modulate the host immune system and keep a healthy microbiota thus enhancing the integrity of the mucosal epithelium. They were proven to be useful as therapeutic strategies for a variety of inflammatory diseases. Preterm birth is a multicausal complication where the early inflammatory cascade activation affects both the mother and the fetus and may have an irreversibly impact on infant development. Prevention of preterm birth is a challenge that calls for different strategies targeting its diverse etiologies. For the past decade, novel and numerous studies investigated the role of probiotics for the prevention of preterm birth given their above-mentioned abilities. This allows a wider approach to the multifactorial causes of preterm birth. In this sense, probiotic administration was shown to be inversely related to the rate of preterm birth. In this review, we discuss the latest reports involving probiotics and preterm birth, and the chances of probiotics becoming a therapeutic strategy for the prevention of pregnancy-associated pathologies like preterm birth shortly.
益生菌可以调节宿主免疫系统，维持健康的微生物群，从而增强黏膜上皮的完整性。事实证明，它们作为多种炎症性疾病的治疗策略是有用的。早产是一种多因素并发症，早期炎症级联反应的激活会影响母亲和胎儿，并且可能对婴儿发育产生不可逆转的影响。预防早产是一项挑战，需要针对其多种病因采取不同的策略。在过去十年中，鉴于益生菌具有上述能力，大量新的研究探讨了益生菌在预防早产方面的作用。这为解决早产的多因素病因提供了更广泛的方法。从这个意义上说，益生菌的使用与早产率呈负相关。在这篇综述中，我们讨论了涉及益生菌和早产的最新报告，以及益生菌在不久的将来成为预防早产等妊娠相关疾病的治疗策略的可能性。
