Assisted Reproduction Unit, Department of Obstetrics and Gynecology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Obstetrics and Gynecology, Key Laboratory of Reproductive Dysfunction, Management of Zhejiang Province, Hangzhou, China.
Front Immunol. 2024 Mar 13;15:1362784. doi: 10.3389/fimmu.2024.1362784. eCollection 2024.
Due to the physiological alteration during pregnancy, maternal gut microbiota changes following the metabolic processes. Recent studies have revealed that maternal gut microbiota is closely associated with the immune microenvironment in utero during pregnancy and plays a vital role in specific pregnancy complications, including preeclampsia, gestational diabetes, preterm birth and recurrent miscarriages. Some other evidence has also shown that aberrant maternal gut microbiota increases the risk of various diseases in the offspring, such as allergic and neurodevelopmental disorders, through the immune alignment between mother and fetus and the possible intrauterine microbiota. Probiotics and the high-fiber diet are effective inventions to prevent mothers and fetuses from diseases. In this review, we summarize the role of maternal gut microbiota in the development of pregnancy complications and the health condition of future generations from the perspective of immunology, which may provide new therapeutic strategies for the health management of mothers and offspring.
由于妊娠期间的生理变化，母体肠道微生物群会随着代谢过程而发生变化。最近的研究表明，母体肠道微生物群与妊娠期间子宫内的免疫微环境密切相关，并在特定的妊娠并发症中发挥重要作用，包括子痫前期、妊娠期糖尿病、早产和反复流产。还有一些证据表明，异常的母体肠道微生物群会通过母婴之间的免疫一致性和可能的宫内微生物群增加后代患各种疾病的风险，如过敏和神经发育障碍。益生菌和高纤维饮食是预防母亲和胎儿患病的有效发明。在这篇综述中，我们从免疫学的角度总结了母体肠道微生物群在妊娠并发症发展和后代健康状况中的作用，这可能为母亲和后代的健康管理提供新的治疗策略。
