Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Eye Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Curr Opin Pharmacol. 2022 Apr;63:102186. doi: 10.1016/j.coph.2022.102186. Epub 2022 Feb 22.
Age-related macular degeneration (AMD) is a progressive retinal disease that is a leading cause of visual impairment and severe vision loss. The number of people affected by AMD is increasing and constitutes a huge worldwide health problem. The beneficial effects of fish consumption on AMD have been revealed over the past decades, and in this review, we summarizes the beneficial effects of fatty fish on AMD and its mechanism of action. Fatty fish affects the development of AMD by inhibiting neovascularization, interacting with retinal pigment epithelial (RPE) cells, displacing Omega-6, and inducing cellular responses. It is recommended that people at high risk or with moderate or more severe AMD should consider eating more fatty fish in addition to maintaining a healthy lifestyle of weight control and smoking cessation and the need to promote new models of personalized AMD prevention and treatment.
年龄相关性黄斑变性（AMD）是一种进行性视网膜疾病，是导致视力损害和严重视力丧失的主要原因。受 AMD 影响的人数正在增加，这构成了一个全球性的巨大健康问题。过去几十年的研究表明，鱼类消费对 AMD 有益，本综述总结了多脂鱼对 AMD 的有益作用及其作用机制。多脂鱼通过抑制新生血管形成、与视网膜色素上皮（RPE）细胞相互作用、取代 Omega-6 和诱导细胞反应来影响 AMD 的发展。建议高危人群或患有中度或更严重 AMD 的人群除了保持健康的生活方式（包括控制体重和戒烟）外，还应考虑多吃多脂鱼，并需要推广新的 AMD 预防和治疗个体化模式。
