• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

腹部照射大鼠小肠中酰基肉碱水平的升高可能与脂肪酸β-氧化途径失衡有关。

Enhancement of Acylcarnitine Levels in Small Intestine of Abdominal Irradiation Rats Might Relate to Fatty Acid β-Oxidation Pathway Disequilibration.

作者信息

Liu Hai-Xiang, Lu Xue, Zhao Hua, Li Shuang, Gao Ling, Tian Mei, Liu Qing-Jie

机构信息

China CDC Key Laboratory of Radiological Protection and Nuclear Emergency, National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing, China.

出版信息

Dose Response. 2022 Feb 22;20(1):15593258221075118. doi: 10.1177/15593258221075118. eCollection 2022 Jan-Mar.

DOI:10.1177/15593258221075118
PMID:35221822
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8874182/
Abstract

OBJECTIVE

This study aims to analyze the alteration of carnitine profile in the small intestine of abdominal irradiation-induced intestinal injury rats and explore the possible reason for the altered carnitine profile.

METHODS

The abdomens of 15 male Sprague Dawley (SD) rats were irradiated with 0, 10, and 15 Gy of Co gamma rays. The carnitine profile in the small intestine and plasma samples of SD rats at 72 h after abdominal irradiated with 0 Gy or 10 Gy of Co gamma rays were measured by targeted metabolomics. The changes of fatty acid β-oxidation (FAO), including the expression of carnitine palmitoyltransferase 1 (CPT1) and acyl-CoA dehydrogenases, were analyzed in the small intestine samples of SD rats after exposed to 0, 10, and 15 Gy groups.

RESULTS

There were eleven acylcarnitines in the small intestine and fourteen acylcarnitines in the plasma of the rat model significantly enhanced, respectively (P < .05). The expression level and activity of CPT1 in the small intestine were remarkably increased (P < .05), and the activity of acyl-CoA dehydrogenase in the small intestine was noticeably reduced (P < .01) after abdominal irradiation.

CONCLUSION

The enhanced acylcarnitine levels in the small intestine of abdominal irradiation rats might relate to the FAO pathway disequilibration.

摘要

目的

本研究旨在分析腹部照射诱导的肠道损伤大鼠小肠中肉碱谱的变化，并探讨肉碱谱改变的可能原因。

方法

对15只雄性Sprague Dawley（SD）大鼠腹部分别给予0、10和15 Gy的钴γ射线照射。采用靶向代谢组学方法检测0 Gy或10 Gy钴γ射线腹部照射后72 h SD大鼠小肠和血浆样本中的肉碱谱。分析0、10和15 Gy组SD大鼠小肠样本中脂肪酸β氧化（FAO）的变化，包括肉碱棕榈酰转移酶1（CPT1）和酰基辅酶A脱氢酶的表达。

结果

大鼠模型小肠中有11种酰基肉碱和血浆中有14种酰基肉碱显著增加（P < .05）。腹部照射后，小肠中CPT1的表达水平和活性显著升高（P < .05），小肠中酰基辅酶A脱氢酶的活性显著降低（P < .01）。

结论

腹部照射大鼠小肠中酰基肉碱水平升高可能与FAO途径失衡有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3e/8874182/fecf6b276603/10.1177_15593258221075118-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3e/8874182/003e7dd04493/10.1177_15593258221075118-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3e/8874182/16315566769a/10.1177_15593258221075118-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3e/8874182/3d8a1d32de85/10.1177_15593258221075118-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3e/8874182/3855a682ea5c/10.1177_15593258221075118-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3e/8874182/fecf6b276603/10.1177_15593258221075118-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3e/8874182/003e7dd04493/10.1177_15593258221075118-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3e/8874182/16315566769a/10.1177_15593258221075118-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3e/8874182/3d8a1d32de85/10.1177_15593258221075118-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3e/8874182/3855a682ea5c/10.1177_15593258221075118-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b3e/8874182/fecf6b276603/10.1177_15593258221075118-fig5.jpg

相似文献

1
Enhancement of Acylcarnitine Levels in Small Intestine of Abdominal Irradiation Rats Might Relate to Fatty Acid β-Oxidation Pathway Disequilibration.腹部照射大鼠小肠中酰基肉碱水平的升高可能与脂肪酸β-氧化途径失衡有关。
Dose Response. 2022 Feb 22;20(1):15593258221075118. doi: 10.1177/15593258221075118. eCollection 2022 Jan-Mar.
2
CPT1 Mediated Ionizing Radiation-Induced Intestinal Injury Proliferation via Shifting FAO Metabolism Pathway and Activating the ERK1/2 and JNK Pathway.CPT1 通过改变 FAO 代谢途径和激活 ERK1/2 和 JNK 通路介导电离辐射诱导的肠道损伤增殖。
Radiat Res. 2022 Nov 1;198(5):488-507. doi: 10.1667/RADE-21-00174.1.
3
CPT1 Mediated Ionizing Radiation-Induced Intestinal Injury Proliferation via Shifting FAO Metabolism Pathway and Activating the ERK1/2 and JNK Pathway.CPT1通过改变脂肪酸氧化代谢途径并激活ERK1/2和JNK途径介导电离辐射诱导的肠道损伤增殖。
Radiat Res. 2022 Aug 17. doi: 10.1667/21-00174.1.
4
Characterization of L-aminocarnitine, an inhibitor of fatty acid oxidation.L-氨基肉碱的特性研究，一种脂肪酸氧化抑制剂。
Mol Genet Metab. 2008 Apr;93(4):403-10. doi: 10.1016/j.ymgme.2007.11.001. Epub 2008 Feb 20.
5
Distribution of carnitine and acylcarnitine in small intestine of carnitine-supplemented and fasted rats.补充肉碱和禁食大鼠小肠中肉碱和酰基肉碱的分布
J Nutr. 1985 Jul;115(7):865-71. doi: 10.1093/jn/115.7.865.
6
Malonyl-CoA and the regulation of fatty acid oxidation in soleus muscle.丙二酰辅酶A与比目鱼肌中脂肪酸氧化的调节
Biochem J. 1998 Aug 15;334 ( Pt 1)(Pt 1):233-41. doi: 10.1042/bj3340233.
7
Relationship between acid-soluble carnitine and coenzyme A pools in vivo.体内酸溶性肉碱与辅酶A库之间的关系。
Biochem J. 1980 Sep 15;190(3):495-504. doi: 10.1042/bj1900495.
8
Quantitation of acyl-CoA and acylcarnitine esters accumulated during abnormal mitochondrial fatty acid oxidation.异常线粒体脂肪酸氧化过程中积累的酰基辅酶A和酰基肉碱酯的定量分析。
J Biol Chem. 1991 Dec 5;266(34):22932-8.
9
Differences between acylcarnitine profiles in plasma and bloodspots.血浆和血斑中酰基肉碱谱的差异。
Mol Genet Metab. 2013 Sep-Oct;110(1-2):116-21. doi: 10.1016/j.ymgme.2013.04.008. Epub 2013 Apr 13.
10
CR reprograms acetyl-CoA metabolism and induces long-chain acyl-CoA dehydrogenase and CrAT expression.CR 重编程乙酰辅酶 A 代谢，并诱导长链酰基辅酶 A 脱氢酶和 CrAT 的表达。
Aging Cell. 2020 Nov;19(11):e13266. doi: 10.1111/acel.13266. Epub 2020 Oct 26.

引用本文的文献

1
Metabolomic Signatures Associated with Radiation-Induced Lung Injury by Correlating Lung Tissue to Plasma in a Rat Model.在大鼠模型中通过将肺组织与血浆相关联确定与辐射诱导的肺损伤相关的代谢组学特征
Metabolites. 2023 Sep 17;13(9):1020. doi: 10.3390/metabo13091020.

本文引用的文献

1
Identification of Potential Radiation Responsive Metabolic Biomarkers in Plasma of Rats Exposed to Different Doses of Cobalt-60 Gamma Rays.不同剂量钴-60γ射线照射大鼠血浆中潜在辐射响应代谢生物标志物的鉴定
Dose Response. 2020 Dec 15;18(4):1559325820979570. doi: 10.1177/1559325820979570. eCollection 2020 Oct-Dec.
2
Metabolomic profiling reveals amino acid and carnitine alterations as metabolic signatures in psoriasis.代谢组学分析揭示了氨基酸和肉碱的改变是银屑病的代谢特征。
Theranostics. 2021 Jan 1;11(2):754-767. doi: 10.7150/thno.51154. eCollection 2021.
3
Effects of fasting, feeding and exercise on plasma acylcarnitines among subjects with CPT2D, VLCADD and LCHADD/TFPD.
CPT2D、VLCADD 和 LCHADD/TFPD 患者禁食、进食和运动对血浆酰基肉碱的影响。
Mol Genet Metab. 2020 Sep-Oct;131(1-2):90-97. doi: 10.1016/j.ymgme.2020.09.001. Epub 2020 Sep 6.
4
Clinical and biochemical outcomes of patients with medium-chain acyl-CoA dehydrogenase deficiency.中链酰基辅酶 A 脱氢酶缺乏症患者的临床和生化结局。
Mol Genet Metab. 2020 Jan;129(1):13-19. doi: 10.1016/j.ymgme.2019.11.006. Epub 2019 Nov 25.
5
CPT1A/2-Mediated FAO Enhancement-A Metabolic Target in Radioresistant Breast Cancer.CPT1A/2介导的脂肪酸氧化增强——放射抗性乳腺癌的一个代谢靶点
Front Oncol. 2019 Nov 15;9:1201. doi: 10.3389/fonc.2019.01201. eCollection 2019.
6
Identification of potential radiation-responsive biomarkers based on human orthologous genes with possible roles in DNA repair pathways by comparison between Arabidopsis thaliana and homo sapiens.基于拟南芥和人类同源基因在 DNA 修复途径中可能发挥的作用，通过比较鉴定具有潜在辐射反应性的生物标志物。
Sci Total Environ. 2020 Feb 1;702:135076. doi: 10.1016/j.scitotenv.2019.135076. Epub 2019 Nov 1.
7
Hyperacetylation of Cardiac Mitochondrial Proteins Is Associated with Metabolic Impairment and Sirtuin Downregulation after Chronic Total Body Irradiation of ApoE Mice.慢性全身体照射 ApoE 小鼠后心脏线粒体蛋白的高乙酰化与代谢损伤和沉默调节蛋白下调有关。
Int J Mol Sci. 2019 Oct 22;20(20):5239. doi: 10.3390/ijms20205239.
8
Progress in cancer survival, mortality, and incidence in seven high-income countries 1995-2014 (ICBP SURVMARK-2): a population-based study.1995-2014 年七个高收入国家癌症存活率、死亡率和发病率的进展（ICBP SURVMARK-2）：一项基于人群的研究。
Lancet Oncol. 2019 Nov;20(11):1493-1505. doi: 10.1016/S1470-2045(19)30456-5. Epub 2019 Sep 11.
9
Metabolomic Studies of Tissue Injury in Nonhuman Primates Exposed to Gamma-Radiation.非人类灵长类动物暴露于伽马辐射后的组织损伤代谢组学研究。
Int J Mol Sci. 2019 Jul 9;20(13):3360. doi: 10.3390/ijms20133360.
10
Liquid Chromatography-Mass Spectrometry-Based Metabolomics of Nonhuman Primates after 4 Gy Total Body Radiation Exposure: Global Effects and Targeted Panels.非人类灵长类动物全身 4 Gy 辐射暴露后的基于液相色谱-质谱联用的代谢组学研究：整体效应和靶向面板。
J Proteome Res. 2019 May 3;18(5):2260-2269. doi: 10.1021/acs.jproteome.9b00101. Epub 2019 Mar 18.