Biomedical Engineering Department, Jordan University of Science and Technology, Irbid 22110, Jordan.
Department of Biomedical Engineering, Rathinam Technical Campus, Coimbatore, India.
Comput Math Methods Med. 2022 Feb 18;2022:5975228. doi: 10.1155/2022/5975228. eCollection 2022.
The mechanical heart valve is a crucial solution for many patients. However, it cannot function on the state of blood as human tissue valves. Thus, people with mechanical valves are put under anticoagulant therapy. A good measurement of the state of blood and how long it takes blood to form clots is the prothrombin time (PT); moreover, it is an indicator of how well the anticoagulant therapy is, and of whether the response of the patient to the drug is as needed. For a more specific standardized measurement of coagulation time, an international normalized ratio (INR) is established. Clinical testing of INR and PT is relatively easy. However, it requires the patient to visit the clinic for evaluation purposes. Many techniques are therefore being developed to provide PT and INR self-testing devices. Unfortunately, those solutions are either inaccurate, complex, or expensive. The present work approaches the design of an anticoagulation self-monitoring device that is easy to use, accurate, and relatively inexpensive. Hence, a two-channel polymethyl methacrylate-based microfluidic point-of-care (POC) smart device has been developed. The Arduino based lab-on-a-chip device applies optical properties to a small amount of blood. The achieved accuracy is 96.7%.
机械心脏瓣膜是许多患者的重要解决方案。然而，它不能像人体组织瓣膜那样在血液状态下工作。因此，使用机械瓣膜的人需要接受抗凝治疗。凝血酶原时间（PT）是衡量血液状态和血液凝结所需时间的一个很好的指标；此外，它还可以反映抗凝治疗的效果，以及患者对药物的反应是否符合需要。为了更具体地标准化凝血时间的测量，建立了国际标准化比值（INR）。INR 和 PT 的临床检测相对简单。然而，这需要患者到诊所进行评估。因此，许多技术都在被开发，以提供 PT 和 INR 的自我检测设备。不幸的是，这些解决方案要么不准确，要么复杂，要么昂贵。本工作采用易于使用、准确且相对便宜的抗凝自我监测设备的设计。因此，开发了一种基于聚甲基丙烯酸甲酯的双通道微流控即时（POC）智能设备。基于 Arduino 的芯片实验室设备利用光学特性对少量血液进行检测。该设备的准确率为 96.7%。
