Fletcher C D, Powell G, McKee P H
Histopathology. 1986 May;10(5):489-99. doi: 10.1111/j.1365-2559.1986.tb02500.x.
In reviewing a large series of soft tissue sarcomas, nine cases of extraskeletal myxoid chondrosarcoma have been retrieved. These tumours, which principally presented in middle-aged adults, have been examined histochemically to determine the heteroglycan content of their myxoid matrix and immunohistochemically for the presence of S-100 protein. The principal mucopolysaccharides identified were chondroitin-4 and 6-sulphate and keratan sulphate; each of the tumours was S-100 positive. The relevance of these findings to the histogenesis and differential diagnosis of these uncommon neoplasms is discussed.
在回顾一大系列软组织肉瘤时，检索到9例骨外黏液样软骨肉瘤。这些肿瘤主要发生于中年成年人，已进行组织化学检查以确定其黏液样基质中的杂聚糖含量，并进行免疫组织化学检查以检测S-100蛋白的存在。鉴定出的主要黏多糖为硫酸软骨素-4和-6以及硫酸角质素；每例肿瘤S-100均呈阳性。讨论了这些发现与这些罕见肿瘤的组织发生及鉴别诊断的相关性。
