Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of the Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi'an, China, 710127.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China, 610064.
ACS Nano. 2022 Mar 22;16(3):4734-4745. doi: 10.1021/acsnano.1c11589. Epub 2022 Feb 28.
Biomineralized tough hydrogels (BTHs) have advanced applications in the fields of soft bioelectronics and biomimetic tissue engineering. But the development of rapid and general photomineralization strategies for one-step fabrication of customizable BTHs is still a challenging task. Here we report a straightforward, low-cost visible-light-mediated nano-biomineralization (VLMNB) strategy a rational design of a phosphate source and efficient ruthenium photochemistry. Multinetwork tough hydrogels are simultaneously constructed under the same condition. Therefore, BTHs are rapidly prepared in a short time as low as ∼60 s under visible light irradiation. The formation of calcium phosphate particles can improve BTHs' mechanical and biological properties and reduce the friction coefficient with bones. Furthermore, fast biomineralization and solidification processes in these BTHs benefit their injectable and highly flexible customizable design, showing applications of promoting customizable skin repair and bone regeneration.
生物矿化坚韧水凝胶（BTHs）在软生物电子学和仿生组织工程领域有广泛的应用。但开发快速且通用的光矿化策略，用于一步式定制 BTH 的制造，仍然是一个具有挑战性的任务。在这里，我们报告了一种简单、低成本的可见光介导纳米矿化（VLMNB）策略，其通过合理设计磷酸盐源和高效的钌光化学。在相同条件下，同时构建了多网络坚韧水凝胶。因此，BTHs 可以在可见光照射下，在极短的时间内（低至约 60 秒）快速制备。磷酸钙颗粒的形成可以提高 BTHs 的机械和生物学性能，并降低与骨骼的摩擦系数。此外，这些 BTHs 中的快速生物矿化和固化过程有利于其可注射和高度灵活的定制设计，在促进定制化皮肤修复和骨再生方面有应用。
