Omidian Hossein, Chowdhury Sumana Dey
Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.
Gels. 2023 Jun 30;9(7):533. doi: 10.3390/gels9070533.
Injectable hydrogels have gained popularity for their controlled release, targeted delivery, and enhanced mechanical properties. They hold promise in cardiac regeneration, joint diseases, postoperative analgesia, and ocular disorder treatment. Hydrogels enriched with nano-hydroxyapatite show potential in bone regeneration, addressing challenges of bone defects, osteoporosis, and tumor-associated regeneration. In wound management and cancer therapy, they enable controlled release, accelerated wound closure, and targeted drug delivery. Injectable hydrogels also find applications in ischemic brain injury, tissue regeneration, cardiovascular diseases, and personalized cancer immunotherapy. This manuscript highlights the versatility and potential of injectable hydrogel nanocomposites in biomedical research. Moreover, it includes a perspective section that explores future prospects, emphasizes interdisciplinary collaboration, and underscores the promising future potential of injectable hydrogel nanocomposites in biomedical research and applications.
可注射水凝胶因其控释、靶向递送和增强的机械性能而受到欢迎。它们在心脏再生、关节疾病、术后镇痛和眼部疾病治疗方面具有前景。富含纳米羟基磷灰石的水凝胶在骨再生方面显示出潜力，可应对骨缺损、骨质疏松症和肿瘤相关再生的挑战。在伤口管理和癌症治疗中，它们能够实现控释、加速伤口愈合和靶向药物递送。可注射水凝胶还应用于缺血性脑损伤、组织再生、心血管疾病和个性化癌症免疫治疗。本手稿强调了可注射水凝胶纳米复合材料在生物医学研究中的多功能性和潜力。此外，它还包括一个展望部分，探讨了未来前景，强调了跨学科合作，并强调了可注射水凝胶纳米复合材料在生物医学研究和应用中充满希望的未来潜力。
