Perforated demineralized bone matrix: a new form of osteoinductive biomaterial.

This study was undertaken to evaluate a new osteoinductive material--perforated decalcified bone matrix (PDBM). Subcutaneous implantation of PDBM induces multiple centers of endochondral osteogenesis with subsequent resorption of bone matrix and its replacement by new bone. PDBM should therefore prove useful as a research model to study osteoinduction and in the clinical situation in orthopedic and reconstructive surgery for the filling of bone defects and stimulation of fracture healing.