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Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole.影响诺卡氏菌属对甲氧苄啶-磺胺甲恶唑敏感性的因素。
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本文引用的文献

1
Antagonists of nucleic acid derivatives. VIII. Synergism in combinations of biochemically related antimetabolites.核酸衍生物拮抗剂。VIII. 生物化学相关抗代谢物组合中的协同作用。
J Biol Chem. 1954 Jun;208(2):477-88.
2
Nocardiosis: diagnosis and management, with a report of three cases.
Med J Aust. 1971 Mar 27;1(13):669-74. doi: 10.5694/j.1326-5377.1971.tb87784.x.
3
Trimethoprim as a possible therapy for nocardiosis and melioidosis.甲氧苄啶作为治疗诺卡菌病和类鼻疽病的一种可能疗法。
Med J Aust. 1970 Dec 12;2(24):1123-7. doi: 10.5694/j.1326-5377.1970.tb63387.x.
4
Sensitivity of Nocardia to trimethoprim and sulphonamides in vitro.体外诺卡菌对甲氧苄啶和磺胺类药物的敏感性。
J Clin Pathol. 1970 Jul;23(5):423-6. doi: 10.1136/jcp.23.5.423.
5
Effects in man of prolonged administration of trimethoprim and sulfisoxazole.
Postgrad Med J. 1969 Nov;45:Suppl:46-51.
6
Assay and pharmacokinetics of trimethoprim in man and animals.甲氧苄啶在人和动物体内的测定及药代动力学
Postgrad Med J. 1969 Nov;45:Suppl:32-7.
7
Pulmonary and cerebral nocardial abscess.肺和脑诺卡菌性脓肿
Med J Aust. 1972 Sep 2;2(10):538-40. doi: 10.5694/j.1326-5377.1972.tb47462.x.
8
Treatment of nocardial infection with trimethoprim and sulfamethoxazole.
Am J Med. 1974 Oct;57(4):671-5. doi: 10.1016/0002-9343(74)90022-9.
9
Treatment of nocardial infection with trimethoprim-sulphamethoxazole.用复方新诺明治疗诺卡菌感染。
Med J Aust. 1973 Jun 30;1(2):Suppl:65-9.
10
Pulmonary nocardiosis complicating malignant lymphoma successfully treated with chemotherapy.肺诺卡菌病合并恶性淋巴瘤经化疗成功治愈。
Chest. 1973 Mar;63(3):367-70. doi: 10.1378/chest.63.3.367.

影响诺卡氏菌属对甲氧苄啶-磺胺甲恶唑敏感性的因素。

Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole.

作者信息

Bennett J E, Jennings A E

出版信息

Antimicrob Agents Chemother. 1978 Apr;13(4):624-7. doi: 10.1128/AAC.13.4.624.

DOI:10.1128/AAC.13.4.624
PMID:352260
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352299/
Abstract

Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation, and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercial, fixed-dose combination was found to contain too little trimethoprim to be optimal for Nocardia.

摘要

已发现甲氧苄啶和磺胺甲恶唑对10株诺卡菌分离株的协同作用关键取决于分离株、孵育时间以及甲氧苄啶与磺胺甲恶唑的比例。接种量效应不显著。发现市售固定剂量复方制剂中的甲氧苄啶与磺胺甲恶唑比例中,甲氧苄啶含量过低,对诺卡菌而言并非最佳。