影响诺卡氏菌属对甲氧苄啶-磺胺甲恶唑敏感性的因素。
Factors influencing susceptibility of Nocardia species to trimethoprim-sulfamethoxazole.
作者信息
Bennett J E, Jennings A E
出版信息
Antimicrob Agents Chemother. 1978 Apr;13(4):624-7. doi: 10.1128/AAC.13.4.624.
Abstract
Demonstration of synergism between trimethoprim and sulfamethoxazole against 10 Nocardia isolates was found to be critically dependent upon the isolate, the duration of incubation, and the trimethoprim-sulfamethoxazole ratio. Inoculum effect was not significant. The trimethoprim-sulfamethoxazole ratio in the commercial, fixed-dose combination was found to contain too little trimethoprim to be optimal for Nocardia.
摘要
已发现甲氧苄啶和磺胺甲恶唑对10株诺卡菌分离株的协同作用关键取决于分离株、孵育时间以及甲氧苄啶与磺胺甲恶唑的比例。接种量效应不显著。发现市售固定剂量复方制剂中的甲氧苄啶与磺胺甲恶唑比例中，甲氧苄啶含量过低，对诺卡菌而言并非最佳。
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