Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, and International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education, Jinan University, Guangzhou 510632, China.
Shengshitaiyan (Guangdong) Health Tech Ltd., Nanhai District, Foshan 528231, China.
Mini Rev Med Chem. 2022;22(17):2287-2298. doi: 10.2174/1389557522666220228150127.
Superoxide dismutase (SOD) is a well-known cellular antioxidant enzyme. However, exogenous SOD cannot be used to protect tissues from oxidative damage due to the low permeability of the cell membrane. Cell-penetrating peptides (CPPs) are a class of short peptides that can cross the cell membrane. Recombinant fusion protein that fuses SOD protein with CPP (CPP-SOD) can cross various tissues and organs as well as the blood-brain barrier. CPP-SODs can relieve severe oxidative damage in various tissues caused by radiation, ischemia, inflammation, and chemotherapy by clearing the reactive oxygen species, reducing the expression of inflammatory factors, and inhibiting NF-κB/MAPK signaling pathways. Therefore, the clinical application of CPP-SODs provides new therapeutic strategies for a variety of oxidative stress-related disorders, such as Parkinson's disease, diabetes, obesity, cardiac fibrosis, and premature aging.
超氧化物歧化酶（SOD）是一种众所周知的细胞抗氧化酶。然而，由于细胞膜的低通透性，外源性 SOD 不能用于保护组织免受氧化损伤。细胞穿透肽（CPP）是一类可以穿过细胞膜的短肽。与 CPP 融合的重组融合蛋白 SOD（CPP-SOD）可以穿过各种组织和器官以及血脑屏障。CPP-SOD 通过清除活性氧、降低炎症因子的表达和抑制 NF-κB/MAPK 信号通路，可缓解辐射、缺血、炎症和化疗引起的各种组织的严重氧化损伤。因此，CPP-SOD 的临床应用为帕金森病、糖尿病、肥胖症、心脏纤维化和早衰等多种与氧化应激相关的疾病提供了新的治疗策略。
