Zhou Yang, Liu Rui, Shevtsov Maxim, Gao Huile
Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610064, PR China.
Institute of Cytology of the Russian Academy of Sciences (RAS), St. Petersburg 194064, Russia.
Adv Drug Deliv Rev. 2022 Apr;183:114176. doi: 10.1016/j.addr.2022.114176. Epub 2022 Feb 25.
Imaging techniques, including magnetic, optical, acoustic and nuclear imaging, are gaining popularity as a research tool and clinical diagnostics. The advent of imaging agents-incorporated nanosystems (NSs), with sufficient contrast and high resolution, facilitates better monitoring of disease progression, targeted delivery and therapeutic process. Of note, the size of NSs remarkably affects imaging performance, while both large and small NSs enjoy respective features and superiority for imaging aspect, including penetration depth, signal-to-background ratio and spatiotemporal resolution. In this review, after a systematic summary of the basic knowledge of imaging techniques and its relation with size-tunable strategies, we further provide insights into the opportunities and challenges facing size-transformable NSs of the future for bio-imaging application and clinical translation.
成像技术，包括磁成像、光学成像、声学成像和核成像，作为一种研究工具和临床诊断手段正越来越受到欢迎。包含成像剂的纳米系统（NSs）的出现，具有足够的对比度和高分辨率，有助于更好地监测疾病进展、靶向递送和治疗过程。值得注意的是，纳米系统的尺寸显著影响成像性能，而大尺寸和小尺寸的纳米系统在成像方面都有各自的特点和优势，包括穿透深度、信噪比和时空分辨率。在本综述中，在系统总结成像技术的基本知识及其与尺寸可调策略的关系之后，我们进一步深入探讨了未来可尺寸转变的纳米系统在生物成像应用和临床转化方面所面临的机遇和挑战。
