International Joint Research Center for Molecular Science, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen, 518060, China.
College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen, 518060, China.
Adv Mater. 2020 Dec;32(48):e2003752. doi: 10.1002/adma.202003752. Epub 2020 Oct 26.
The size of nanostructures (NSs) strongly affects their chemical and physical properties and further impacts their actions in biological systems. Both small and large NSs possess respective advantages for disease theranostics, and this therefore presents a paradox when choosing NSs with suitable sizes. To overcome this challenge, size-transformable NSs have emerged as a powerful tool, as they can be manipulated to possess the merits of both types of NSs. Herein, various strategies to construct size-transformable NSs are summarized, and the recent research progress regarding their biomedical applications, particularly within the fields of cancer and bacterial theranostics, is highlighted. This review will inspire researchers to further develop various methods that can be used to construct size-transformable NSs for use in novel applications within different fields.
纳米结构（NSs）的尺寸强烈影响其化学和物理性质，并进一步影响它们在生物系统中的作用。小尺寸和大尺寸的 NSs 各自在疾病治疗诊断方面具有优势，因此在选择具有合适尺寸的 NSs 时存在矛盾。为了克服这一挑战，尺寸可转换的 NSs 作为一种强大的工具出现了，因为它们可以被操纵以同时具有两种类型的 NSs 的优点。本文总结了各种构建尺寸可转换 NSs 的策略，并强调了它们在生物医学应用，特别是癌症和细菌治疗诊断领域的最新研究进展。这篇综述将激发研究人员进一步开发各种方法，用于构建尺寸可转换 NSs，以应用于不同领域的新应用。
