An epidemiology-based model for the operational allocation of COVID-19 vaccines: A case study of Thailand.

This paper addresses a framework for the operational allocation and administration of COVID-19 vaccines in Thailand, based on both COVID-19 transmission dynamics and other vital operational restrictions that might affect the effectiveness of vaccination strategies in the early stage of vaccine rollout. In this framework, the SIQRV model is first developed and later combined with the COVID-19 Vaccine Allocation Problem (CVAP) to determine the optimal allocation/administration strategies that minimize total weighted strain on the whole healthcare system. According to Thailand's second pandemic wave data (17 January 2021, to 15 February 2021), we find that the epicenter-based strategy is surprisingly the worst allocation strategy, due largely to the negligence of provincial demographics, vaccine efficacy, and overall transmission dynamics that lead to higher number of infectious individuals. We also find that early vaccination seems to significantly contribute to the reduction in the number of infectious individuals, whose effects tend to increase with more vaccine supply. With these insights, healthcare policy-makers should therefore focus not only on the procurement of COVID-19 vaccines at strategic levels but also on the allocation and administration of such vaccines at operational levels for the best of their limited vaccine supply.