Mitra Souradeep, Mateti Tarun, Ramakrishna Seeram, Laha Anindita
Department of Chemical Engineering, Manipal Institute of Technology, Manipal Academy of Higher Education, Manipal - 576104 Udupi, Karnataka India.
Center of Nanofibers and Nanotechnology, National University of Singapore, Singapore, 117581 Singapore.
JOM (1989). 2022;74(9):3392-3407. doi: 10.1007/s11837-022-05180-9. Epub 2022 Feb 24.
Herbal drugs are safe and show significantly fewer side effects than their synthetic counterparts. Curcumin (an active ingredient primarily found in turmeric) shows therapeutic properties, but its commercial use as a medication is unrealized, because of doubts about its potency. The literature reveals that electrospun nanofibers show simplicity, efficiency, cost, and reproducibility compared to other fabricating techniques. Forcespinning is a new technique that minimizes limitations and provides additional advantages to electrospinning. Polymer-based nanofibers-whose advantages lie in stability, solubility, and drug storage-overcome problems related to drug delivery, like instability and hydrophobicity. Curcumin-loaded polymer nanofibers show potency in healing diabetic wounds in vitro and in vivo. The release profiles, cell viability, and proliferation assays substantiate their efficacy in bone tissue repair and drug delivery against lung, breast, colorectal, squamous, glioma, and endometrial cancer cells. This review mainly discusses how polymer nanofibers interact with curcumin and its medical efficacy.
草药比合成药物更安全，副作用也明显更少。姜黄素（主要存在于姜黄中的一种活性成分）具有治疗特性，但由于对其效力存在疑虑，它尚未作为药物实现商业应用。文献表明，与其他制造技术相比，电纺纳米纤维具有简单、高效、成本低和可重复性等优点。强力纺丝是一种新技术，它最大限度地减少了局限性，并为电纺丝提供了额外的优势。基于聚合物的纳米纤维——其优点在于稳定性、溶解性和药物储存——克服了与药物递送相关的问题，如不稳定性和疏水性。负载姜黄素的聚合物纳米纤维在体外和体内对糖尿病伤口愈合均显示出效力。释放曲线、细胞活力和增殖试验证实了它们在骨组织修复以及针对肺癌、乳腺癌、结直肠癌、鳞状细胞癌、胶质瘤和子宫内膜癌细胞的药物递送方面的功效。本综述主要讨论聚合物纳米纤维如何与姜黄素相互作用及其医学功效。
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