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纳米孔检测癌症生物标志物:对科学的挑战。

Nanopore Detection of Cancer Biomarkers: A Challenge to Science.

机构信息

Southeast University, Nanjing, People's Republic of China.

出版信息

Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221076669. doi: 10.1177/15330338221076669.

DOI:10.1177/15330338221076669
PMID:35229683
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8891933/
Abstract

Cancer is the most complex and leading cause of fatality worldwide. Despite meritorious research in the field of cancer, it is still a substantial threat to human life. In this article, we address a question on the present strategies and manifest the importance of critical biomarkers for cancer screening and early diagnosis before the symptoms appear. However, this goal can only be achieved if scientists will focus on ultra-sensitive detection techniques such as "Nanopore." Nanopore sensing is a simple and rapid single-molecule detection technique that can detect multiple cancer biomarkers in femto-Molar concentrations in real time. Last but not least, we propose a systematic policy to win the war against cancer that is a big challenge to science.

摘要

癌症是全球最复杂和主要的致死原因。尽管在癌症领域进行了卓越的研究,但它仍然对人类生命构成重大威胁。在本文中,我们探讨了一个关于当前策略的问题,并强调了在症状出现之前进行癌症筛查和早期诊断的关键生物标志物的重要性。然而,如果科学家们专注于超灵敏的检测技术,如“纳米孔”,这一目标才有可能实现。纳米孔传感是一种简单快速的单分子检测技术,可以实时检测纳摩尔浓度的多种癌症生物标志物。最后但同样重要的是,我们提出了一个系统的政策来赢得这场对科学界来说是一个巨大挑战的抗癌战争。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25cf/8891933/fd17cc4a576a/10.1177_15330338221076669-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25cf/8891933/fd17cc4a576a/10.1177_15330338221076669-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25cf/8891933/fd17cc4a576a/10.1177_15330338221076669-fig1.jpg

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本文引用的文献

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RSC Adv. 2021 Aug 31;11(46):28996-29014. doi: 10.1039/d1ra02364k. eCollection 2021 Aug 23.
2
Direct detection of RNA modifications and structure using single-molecule nanopore sequencing.使用单分子纳米孔测序直接检测RNA修饰和结构
Cell Genom. 2022 Feb 9;2(2). doi: 10.1016/j.xgen.2022.100097.
3
Accurate detection of circulating tumor DNA using nanopore consensus sequencing.
使用纳米孔一致性测序准确检测循环肿瘤DNA。
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Biomater Sci. 2021 Dec 21;10(1):167-177. doi: 10.1039/d1bm01264a.
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Sequencing DNA with nanopores: Troubles and biases.用纳米孔测序 DNA:问题和偏差。
PLoS One. 2021 Oct 1;16(10):e0257521. doi: 10.1371/journal.pone.0257521. eCollection 2021.
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Int J Cancer. 2021 Apr 5. doi: 10.1002/ijc.33588.
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Glutathione Content Detection of Single Cells under Ingested Doxorubicin by Functionalized Glass Nanopores.功能化玻璃纳米孔对摄入阿霉素的单细胞谷胱甘肽含量检测
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