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纳米孔检测癌症生物标志物:对科学的挑战。

Nanopore Detection of Cancer Biomarkers: A Challenge to Science.

机构信息

Southeast University, Nanjing, People's Republic of China.

出版信息

Technol Cancer Res Treat. 2022 Jan-Dec;21:15330338221076669. doi: 10.1177/15330338221076669.

Abstract

Cancer is the most complex and leading cause of fatality worldwide. Despite meritorious research in the field of cancer, it is still a substantial threat to human life. In this article, we address a question on the present strategies and manifest the importance of critical biomarkers for cancer screening and early diagnosis before the symptoms appear. However, this goal can only be achieved if scientists will focus on ultra-sensitive detection techniques such as "Nanopore." Nanopore sensing is a simple and rapid single-molecule detection technique that can detect multiple cancer biomarkers in femto-Molar concentrations in real time. Last but not least, we propose a systematic policy to win the war against cancer that is a big challenge to science.

摘要

癌症是全球最复杂和主要的致死原因。尽管在癌症领域进行了卓越的研究,但它仍然对人类生命构成重大威胁。在本文中,我们探讨了一个关于当前策略的问题,并强调了在症状出现之前进行癌症筛查和早期诊断的关键生物标志物的重要性。然而,如果科学家们专注于超灵敏的检测技术,如“纳米孔”,这一目标才有可能实现。纳米孔传感是一种简单快速的单分子检测技术,可以实时检测纳摩尔浓度的多种癌症生物标志物。最后但同样重要的是,我们提出了一个系统的政策来赢得这场对科学界来说是一个巨大挑战的抗癌战争。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/25cf/8891933/fd17cc4a576a/10.1177_15330338221076669-fig1.jpg

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