Antuña Eduardo, Carlos Bermejo-Millo Juan, Caso-Onzain Enrique, Caso-Peláez Enrique, Potes Yaiza, Coto-Montes Ana
Department of Morphology and Cell Biology, Faculty of Medicine, University of Oviedo, Oviedo, Spain.
Instituto de Investigación Sanitaria Del Principado de Asturias (ISPA), Av. Del Hospital Universitario, Oviedo, Spain.
Front Bioeng Biotechnol. 2022 Feb 14;10:800011. doi: 10.3389/fbioe.2022.800011. eCollection 2022.
Currently, industrial activity causes the environmental release of nanoparticles that have multiple adverse effects on population health. There is a clear correlation between the increase in particulate air pollution and the increases in mortality and morbidity rates in both adults and children, which demonstrates the toxic effects of these particles. However, the effect of particle removal on healthy individuals is unknown. Thus, in this preliminary study, we showed, for the first time, how the filtering equipment that we used significantly reduced a large amount of nanoparticles in a minimum time and induced a reduction of oxidative damage in healthy individuals of both sexes after 25, 50 and 100 days of exposure. These effects led to increased protein synthesis and enhanced mitochondrial efficiency, thus resulting in a highly significant triggering of ATP synthesis. These results not only provide insight into the chronic effects that environmental nanoparticles have on individuals prior to the development of pathologies but also demonstrate a system capable of reversing nanoparticle toxicity and allowing cellular energy recovery.
目前,工业活动导致纳米颗粒释放到环境中,对人群健康产生多种不利影响。空气中颗粒物污染的增加与成人和儿童死亡率及发病率的上升之间存在明显的相关性,这表明了这些颗粒的毒性作用。然而,颗粒清除对健康个体的影响尚不清楚。因此,在这项初步研究中,我们首次展示了我们使用的过滤设备如何在最短时间内显著减少大量纳米颗粒,并在暴露25天、50天和100天后,使健康的男女个体的氧化损伤有所减轻。这些作用导致蛋白质合成增加和线粒体效率提高,从而极大地促进了ATP的合成。这些结果不仅让我们深入了解了环境纳米颗粒在疾病发生之前对个体的慢性影响,还证明了一种能够逆转纳米颗粒毒性并使细胞能量得以恢复的系统。