Department of Biology, Düzce University, Düzce, Turkey.
J Cosmet Dermatol. 2022 Oct;21(10):4913-4920. doi: 10.1111/jocd.14891. Epub 2022 Apr 24.
This study aimed to develop a prototype skincare product with bee venom, propolis, honey, beeswax, and royal jelly. The prototype formulation contained 0.1% bee venom, 0.3% propolis extract, 0.45% honey, and 1.0% royal jelly. The prototype body cream was analyzed for stability, antioxidant activity, dermatological response, and cytotoxicity. In addition, a panel test evaluated the prototype for the claims such as skin smoothness, feelings of nourishment, moisturizing, skin tone, brightness, and visibility of wrinkles. According to the stability test, the prototype was stable for up to 90 days at room temperature and +40°C. The formulation was found to have a high antioxidant capacity at 85.45%. Cell viability detected over 70% indicated that the prototype body cream was not cytotoxic. The dermatological analysis revealed no irritation or allergic reaction in non-allergic individuals. Panel test showed that the prototype makes skin silky smooth, contributes to hydration, brightens and nourishes the skin, evens the skin tone, reduces the visibility of wrinkles, improves skin elasticity, and smoothes wrinkles. This prototype formulation requires further research to evaluate its effectiveness against skin aging on different skin types. Nevertheless, the side effects of such products need particular attention in developing a commercial product containing bee venom in susceptible individuals.
本研究旨在开发一种含有蜂毒、蜂胶、蜂蜜、蜂蜡和蜂王浆的护肤品原型。原型配方包含 0.1%蜂毒、0.3%蜂胶提取物、0.45%蜂蜜和 1.0%蜂王浆。对原型体霜进行了稳定性、抗氧化活性、皮肤反应和细胞毒性分析。此外，一个小组测试评估了原型产品的声称，如皮肤光滑度、滋养感、保湿、肤色、亮度和皱纹可见度。根据稳定性测试，原型在室温下和+40°C 下可稳定长达 90 天。该配方具有高达 85.45%的高抗氧化能力。细胞活力检测超过 70%表明原型体霜没有细胞毒性。皮肤分析显示，非过敏个体无刺激或过敏反应。小组测试表明，原型产品使皮肤如丝般光滑，有助于保湿、提亮和滋养肌肤，均匀肤色，减少皱纹的可见度，提高皮肤弹性，抚平皱纹。该原型配方需要进一步研究，以评估其在不同皮肤类型上对抗皮肤衰老的效果。然而，在开发含有蜂毒的商业产品时，需要特别注意此类产品对易敏感个体的副作用。
