Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.
Department of Experimental Psychology, University of Oxford, Oxford, OX2 6GG, UK.
Cereb Cortex. 2022 Dec 20;33(2):458-468. doi: 10.1093/cercor/bhac077.
Goal-directed behavior is dependent upon the ability to detect errors and implement appropriate posterror adjustments. Accordingly, several studies have explored the neural activity underlying error-monitoring processes, identifying the insula cortex as crucial for error awareness and reporting mixed findings with respect to the anterior cingulate cortex (ACC). Variable patterns of activation have previously been attributed to insufficient statistical power. We therefore sought to clarify the neural correlates of error awareness in a large event-related functional magnetic resonance imaging (fMRI) study. Four hundred and two healthy participants undertook the error awareness task, a motor Go/No-Go response inhibition paradigm in which participants were required to indicate their awareness of commission errors. Compared to unaware errors, aware errors were accompanied by significantly greater activity in a network of regions, including the insula cortex, supramarginal gyrus (SMG), and midline structures, such as the ACC and supplementary motor area (SMA). Error awareness activity was related to indices of task performance and dimensional measures of psychopathology in selected regions, including the insula, SMG, and SMA. Taken together, we identified a robust and reliable neural network associated with error awareness.
目标导向行为依赖于检测错误并实施适当的错误后调整的能力。因此，几项研究探讨了错误监测过程背后的神经活动，确定脑岛皮层对于错误意识至关重要，并对前扣带皮层 (ACC) 得出了混合的发现。先前归因于统计能力不足的激活模式的可变性。因此，我们试图在一项大型事件相关功能磁共振成像 (fMRI) 研究中阐明错误意识的神经相关性。402 名健康参与者进行了错误意识任务，这是一个运动 Go/No-Go 反应抑制范式，参与者需要表明他们对犯错的意识。与无意识错误相比，有意识错误伴随着包括脑岛皮层、缘上回 (SMG) 和中线结构（如 ACC 和辅助运动区 (SMA)）在内的一系列区域的显著更大的活动。在选定的区域（包括脑岛、SMG 和 SMA）中，错误意识活动与任务表现指标和精神病理学的维度测量相关。总的来说，我们确定了一个与错误意识相关的强大而可靠的神经网络。
