Fekete Monika, Szollosi Gergo, Tarantini Stefano, Lehoczki Andrea, Nemeth Anna N, Bodola Csenge, Varga Luca, Varga Janos Tamas
1 Department of Public Health, Faculty of Medicine, Semmelweis University, Budapest, Hungary.
2 Department of Family and Occupational Medicine, Faculty of Public Health, University of Debrecen, Debrecen, Hungary.
Physiol Int. 2022 Mar 3. doi: 10.1556/2060.2022.00164.
Decreased physical activity significantly increases the probability of prevalent metabolic syndrome (MetS) with substantial impact on the expected course of COPD.
Our research aims to assess the metabolic consequences of chronic obstructive pulmonary disease (COPD) and evaluate the prevalence of MetS and its interrelations with age, sex, comorbidities, drug intake, degree of decreased lung function, nutritional status, physical activity and quality of life.
A cross-sectional study was performed on a random sample (n = 401) at the Department of Pulmonary Rehabilitation of the National Koranyi Institute of Pulmonology from March 1, 2019 to March 1, 2020 in Budapest, Hungary. Anthropometric and respiratory function tests and laboratory parameters of all patients were registered.
MetS occurred in 59.1% of COPD patients with significant gender difference (male: 49.7% female: 67.6%). Concerning BMI, the prevalence of MetS was higher with BMI≥25 kg m-2 (P < 0.0001). Patients with this syndrome had significantly worse FEV1%pred (43 (30-56) vs. 47 (36-61); P = 0.028), lower quality of life (CAT: 26 (21-32) vs. 24.5 (19-29); P = 0.049) and significantly more frequent exacerbations (2 (1-3) vs.1 (0-2); P < 0.05), than patients without MetS. The prevalence of comorbidities were higher in overweight/obese patients (BMI> 25 kg m-2).
In COPD patients MetS negatively affect respiratory function and quality of life and promotes exacerbations of the disease. MetS is related to nutritional status and the level of systemic inflammation in COPD patients.
身体活动减少会显著增加患代谢综合征（MetS）的概率，对慢性阻塞性肺疾病（COPD）的预期病程有重大影响。
我们的研究旨在评估慢性阻塞性肺疾病（COPD）的代谢后果，评估代谢综合征（MetS）的患病率及其与年龄、性别、合并症、药物摄入、肺功能下降程度、营养状况、身体活动和生活质量的相互关系。
2019年3月1日至2020年3月1日在匈牙利布达佩斯国家科兰伊肺科研究所肺康复科对一个随机样本（n = 401）进行了横断面研究。记录了所有患者的人体测量和呼吸功能测试以及实验室参数。
59.1%的COPD患者发生了MetS，存在显著的性别差异（男性：49.7%；女性：67.6%）。关于体重指数（BMI），BMI≥25 kg/m²时MetS的患病率更高（P < 0.0001）。患有该综合征的患者的预计第一秒用力呼气容积百分比（FEV1%pred）显著更差（43（30 - 56）对47（36 - 61）；P = 0.028），生活质量更低（COPD评估测试（CAT）：26（21 - 32）对24.5（19 - 29）；P = 0.049），且急性加重明显更频繁（2（1 - 3）对1（0 - 2）；P < 0.05），比无MetS的患者。超重/肥胖患者（BMI>25 kg/m²）的合并症患病率更高。
在COPD患者中，MetS对呼吸功能和生活质量产生负面影响，并促进疾病的急性加重。MetS与COPD患者的营养状况和全身炎症水平有关。
