Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Pennington Biomedical Research Center, Baton Rouge, LA, USA; Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany.
Exp Gerontol. 2022 Jun 1;162:111757. doi: 10.1016/j.exger.2022.111757. Epub 2022 Feb 28.
The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE™) phase 2 trial tested the effects of two years of 25% calorie restriction (CR) on aging in humans. CALERIE 2 was one of the first studies to use a graph of predicted weight loss to: 1) provide a proxy of dietary adherence, and 2) promote dietary adherence. Assuming 25% CR, each participant's weight over time was predicted, with upper and lower bounds around predicted weights. Thus, the resulting weight graph included a zone or range of body weights that reflected adherence to 25% CR, and this was named the zone of adherence. Participants were considered adherent if their weight was in this zone. It is unlikely, however, that the entire zone reflects 25% CR.
To determine the level of CR associated with the zone of adherence and if the level of CR achieved by participants was within the zone.
Percent CR associated with the upper and lower bounds of the zone were determined via the Body Weight Planner (https://www.niddk.nih.gov/bwp) for participants in the CALERIE 2 CR group (N = 143). Percent CR achieved by participants was estimated with the intake-balance method.
At month 24, the zone of adherence ranged from 10.4(0.0)% to 19.4(0.0)% CR [Mean(SEM)], and participants achieved 11.9(0.7)% CR and were in the zone.
The results highlight the challenges of: 1) setting a single CR goal vs. a range of acceptable values, and 2) obtaining real-time and valid measures of CR adherence to facilitate adherence.
减少能量摄入的长期效果综合评估（CALERIE™）二期试验测试了两年 25%热量限制（CR）对人类衰老的影响。CALERIE 2 是首批使用预测体重减轻图的研究之一：1）提供饮食依从性的替代指标，2）促进饮食依从性。假设 25%CR，每个参与者的体重随时间变化进行预测，预测体重的上下限。因此，体重图包括一个反映 25%CR 依从性的体重范围或区域，这个区域被命名为依从区。如果参与者的体重在这个区域内，就被认为是依从的。然而，这个区域不太可能完全反映 25%CR。
确定与依从区相关的 CR 水平，以及参与者实际达到的 CR 水平是否在该区域内。
通过 Body Weight Planner（https://www.niddk.nih.gov/bwp）确定 CALERIE 2 CR 组（N=143）参与者依从区上下限的 CR 百分比。通过摄入量平衡法估计参与者实际达到的 CR 百分比。
在 24 个月时，依从区范围为 10.4（0.0）%至 19.4（0.0）% CR [平均值（SEM）]，参与者实际达到 11.9（0.7）% CR 并处于该区域内。
结果强调了以下挑战：1）设定单一的 CR 目标与可接受值范围，2）获得实时和有效的 CR 依从性衡量标准以促进依从性。
