良性和癌症患者的脂质过氧化 (LP) 生物标志物 4-羟壬烯醛 (4-HNE) 的血浆浓度。

Plasma Concentration of the Lipid Peroxidation (LP) Biomarker 4-Ηydroxynonenal (4-HNE) in Benign and Cancer Patients.

机构信息

Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland;

Department of Surgery, Kuopio University Hospital and School of Medicine, University of Eastern Finland, Kuopio, Finland.

出版信息

In Vivo. 2022 Mar-Apr;36(2):773-779. doi: 10.21873/invivo.12764.

DOI:10.21873/invivo.12764

PMID:35241533

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8931927/

Abstract

BACKGROUND/AIM: The present study investigated the plasma concentration of the lipid peroxidation (LP) biomarker 4-hydroxynonenal (4-HNE) in benign and cancer patients having the rectus sheath block (RSB) analgesia after midline laparotomy. Plasma concentrations of catalase (CAT) and malondialdehyde (MDA) were used as a reference.

PATIENTS AND METHODS

This study assessed three LP biomarkers; CAT, MDA and 4-HNE and compared the plasma levels to the patient satisfaction 24 h postoperatively (SFS; 0=fully unsatisfied; 10=fully satisfied); the overall pain at rest (NRS) and when pressing the wound at 20 Newton force (NRS) were surveyed and filed on a 11-point numeric rating scale at 24 h following surgery (NRS; 0=no pain; 10=worst pain). There were 56 patients in the study, of whom 12 were excluded due to missing plasma samples. The final study cohort consisted of 15 patients with benign disease and 29 patients with cancer.

RESULTS

The RSB analgesia enhanced significantly the SFS scores in the study groups (p=0.001). The plasma 4-HNE decreased immediately after operation (POP1) and the postoperative decrease between the preoperative and the POP1 values in the 4-HNE marker were statistically significant (p<0.001). The individual plasma 4-HNE and MDA concentration correlated significantly in benign and cancer patients (r=0.413, p<0.001).

CONCLUSION

The present study confirms the applicability of the plasma biomarker 4-HNE to cast further light on the postoperative pain in midline laparotomy patients.

摘要

背景/目的：本研究调查了经腹正中切口手术后行腹直肌鞘阻滞（RSB）镇痛的良性和癌症患者的血浆脂质过氧化（LP）生物标志物 4-羟基壬烯醛（4-HNE）浓度。同时使用过氧化氢酶（CAT）和丙二醛（MDA）作为参考。

患者和方法

本研究评估了三种 LP 生物标志物；CAT、MDA 和 4-HNE，并将血浆水平与术后 24 小时患者满意度（SFS；0=完全不满意；10=完全满意）进行比较；还对患者术后静息时的总体疼痛（NRS）和在 20 牛顿力按压伤口时的疼痛（NRS）进行了评估，并在术后 24 小时使用 11 点数字评分量表进行记录（NRS；0=无痛；10=最痛）。本研究共有 56 名患者，其中 12 名因缺少血浆样本而被排除。最终的研究队列包括 15 名良性疾病患者和 29 名癌症患者。