Department of Surgery, Yokohama City University, Yokohama, Japan;
Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
In Vivo. 2022 Mar-Apr;36(2):942-948. doi: 10.21873/invivo.12784.
We investigated the influence of the preoperative Controlling Nutritional Status (CONUT) score on survival and recurrence of gastric cancer in patients after curative treatment.
This study included 331 patients who underwent curative surgery followed by adjuvant treatment for gastric cancer between 2013 and 2017. The risk factors for overall survival (OS) and recurrence-free survival (RFS) were identified.
Based on the 1-, 3- and 5-year survival rates, a CONUT score of 2 was regarded as the optimal cut-off value for classification. The 3- and 5-year OS rates were 93.6% and 88.6%, respectively in the low-CONUT group, and 82.7% and 73.6% in high-CONUT group (p=0.022). The 3- and 5-year RFS rates were 78.8% and 68.7%, respectively, in the low-CONUT group, and 89.3% and 86.6%, respectively, in the high-CONUT group (p=0.05). A multivariate analysis showed that the CONUT score was a significant independent predictive factor for OS and RFS.
The CONUT score was a predictive factor for survival in patients who underwent curative treatment for gastric cancer. It is necessary to develop an effective plan for perioperative care and surgical strategy according to the CONUT score.
我们研究了术前控制营养状况（CONUT）评分对接受根治性治疗后胃癌患者生存和复发的影响。
本研究纳入了 2013 年至 2017 年间接受根治性手术和辅助治疗的 331 例胃癌患者。确定了总生存（OS）和无复发生存（RFS）的危险因素。
根据 1、3 和 5 年的生存率，将 CONUT 评分 2 定义为分类的最佳截断值。低 CONUT 组的 3 年和 5 年 OS 率分别为 93.6%和 88.6%，高 CONUT 组分别为 82.7%和 73.6%（p=0.022）。低 CONUT 组的 3 年和 5 年 RFS 率分别为 78.8%和 68.7%，高 CONUT 组分别为 89.3%和 86.6%（p=0.05）。多因素分析显示，CONUT 评分是 OS 和 RFS 的独立预测因素。
CONUT 评分是接受胃癌根治性治疗患者生存的预测因素。根据 CONUT 评分制定有效的围手术期护理和手术策略非常必要。
