Inoue M, Koyanagi T, Nakahara H, Hara K, Hori E, Nakano H
Am J Obstet Gynecol. 1986 Jul;155(1):170-4. doi: 10.1016/0002-9378(86)90105-5.
Functional development of eye movement in the human fetus in utero was assessed quantitatively, with real-time ultrasound. A pair of lens-derived echoes was used as a landmark to evaluate positional deviation with eye movement. The frequency of eye movement was measured either with 1-minute continuous observations or at 1-minute cross sections. Two hundred forty-five normal fetuses between 18 and 42 weeks of gestation were studied. Three critical ages, with respect to physiologic development of fetal eye movements, were evident: 22 to 25, 30 to 33, and 38 to 41 weeks. The first and the second indicate the onset of the moderate-frequency and high-frequency eye movements, thereby implying a transition, presumably to a state of so-called rapid eye movement and a rise of rapid eye movement, respectively. The third represents full maturation of the mechanisms, that is, non-rapid eye movement and rapid eye movement.
利用实时超声对子宫内人类胎儿眼球运动的功能发育进行了定量评估。一对晶状体产生的回声被用作评估眼球运动时位置偏差的标志。眼球运动频率通过1分钟连续观察或1分钟时间间隔进行测量。对245例孕18至42周的正常胎儿进行了研究。关于胎儿眼球运动的生理发育，有三个关键时期很明显：22至25周、30至33周和38至41周。第一个时期和第二个时期分别表明中等频率和高频眼球运动的开始，这意味着分别可能过渡到所谓的快速眼球运动状态和快速眼球运动频率的上升。第三个时期代表机制的完全成熟，即非快速眼球运动和快速眼球运动。
