Pinnock C B, Douglas R M, Badcock N R
Aust Paediatr J. 1986 May;22(2):95-9. doi: 10.1111/j.1440-1754.1986.tb00197.x.
The effect of Vitamin A supplementation on susceptibility to acute respiratory infections was investigated in a randomized controlled trial. One hundred and forty-seven preschool-age children with a history of frequent respiratory illness were randomized into Vitamin A supplemented (450 micrograms/day) and placebo groups. Respiratory symptoms were recorded on a daily basis over a period of 11 months. The children who received the supplement experienced 19% fewer episodes of respiratory symptomatology (P less than 0.05) than their placebo counterparts, despite the fact that their plasma retinol levels did not change. Children with a prior history of lower respiratory illness or of allergy benefited most from supplementation. The plausibility of a role for Vitamin A in the aetiology of respiratory proneness is reviewed.
在一项随机对照试验中，研究了补充维生素A对急性呼吸道感染易感性的影响。147名有频繁呼吸道疾病史的学龄前儿童被随机分为补充维生素A组（450微克/天）和安慰剂组。在11个月的时间里，每天记录呼吸道症状。尽管补充维生素A组儿童的血浆视黄醇水平没有变化，但与安慰剂组儿童相比，他们出现呼吸道症状的次数减少了19%（P<0.05）。有下呼吸道疾病或过敏史的儿童从补充维生素A中获益最大。本文综述了维生素A在呼吸道易感性病因中作用的合理性。
