Padwick M L, Siddle N C, Lane G, Endacott J A, Cooper H, Pryse-Davies J, Whitehead M I
Br J Obstet Gynaecol. 1986 Jun;93(6):606-12. doi: 10.1111/j.1471-0528.1986.tb08034.x.
In a prospective, double-blind, randomized, cross-over trial, the effects of oral oestradiol, 2 mg daily, on the endometrial histology, frequency and severity of vaginal bleeding, and the symptomatic and psychological status of postmenopausal women were compared with those of oral oestradiol, 2 mg daily, plus oestriol, 1 mg daily. Both therapies were prescribed for 3 months on a cyclical basis. The addition of oestriol to oestradiol did not modify the endometrial response. The prevalence of proliferative/hyperplastic endometrium (64%: 9 of 14 biopsies) was similar after both treatments and there were no significant differences in either the frequency or heaviness of vaginal bleeding. Both therapies significantly reduced hot flushes, night sweats and vaginal dryness: no significant differences in effect on the symptomatic and psychological status were recorded. The addition of 1 mg of oestriol to 2 mg of oestradiol did not confer any benefit and the value of such an addition is challenged.
在一项前瞻性、双盲、随机、交叉试验中，将每日口服2毫克雌二醇对绝经后妇女的子宫内膜组织学、阴道出血频率和严重程度以及症状和心理状态的影响，与每日口服2毫克雌二醇加每日1毫克雌三醇的情况进行了比较。两种疗法均按周期服用3个月。在雌二醇中添加雌三醇并未改变子宫内膜的反应。两种治疗后增生性/增生期子宫内膜的患病率（64%：14次活检中有9次）相似，阴道出血的频率或出血量均无显著差异。两种疗法均显著减少潮热、盗汗和阴道干涩：在症状和心理状态方面的效果无显著差异。在2毫克雌二醇中添加1毫克雌三醇没有带来任何益处，这种添加的价值受到质疑。
