Department of Psychiatry, Kobe University Graduate School of Medicine, Kobe, Japan.
Department of Biosignal Pathophysiology, Kobe University Graduate School of Medicine, Kobe, Japan.
Neuropsychopharmacol Rep. 2022 Jun;42(2):174-182. doi: 10.1002/npr2.12243. Epub 2022 Mar 5.
MATRICS Consensus Cognitive Battery was developed by the National Institute of Mental Health to establish acceptance criteria for measuring cognitive changes in schizophrenia and can be used to assess cognitive functions in other psychiatric disorders. We used a Japanese version of MATRICS Consensus Cognitive Battery to explore the changes in multiple cognitive functions in patients with mild cognitive impairment and mild Alzheimer's disease.
We administered the Japanese version of MATRICS Consensus Cognitive Battery to 11 patients with mild cognitive impairment (MCI), 11 patients with Alzheimer's disease, and 27 healthy controls. All Japanese versions of MATRICS Consensus Cognitive Battery domain scores were converted to t-scores using sample means and standard deviations and were compared for significant performance differences among healthy control, MCI, and mild Alzheimer's disease groups.
Compared with healthy controls, patients with MCI and mild Alzheimer's disease demonstrated the same degree of impairment to processing speed, verbal learning, and visual learning. Reasoning and problem-solving showed significant impairments only in mild Alzheimer's disease. Verbal and visual abilities in working memory showed different performances in the MCI and mild Alzheimer's disease groups, with the Alzheimer's disease group demonstrating significantly more deficits in these domains. No significant difference was found among the groups in attention/vigilance and social cognition.
The Japanese version of MATRICS Consensus Cognitive Battery can be used to elucidate the characteristics of cognitive dysfunction of normal aging, MCI, and mild dementia in clinical practice.
MATRICS 共识认知电池由美国国立精神卫生研究所开发，用于建立衡量精神分裂症认知变化的接受标准，可用于评估其他精神障碍的认知功能。我们使用 MATRICS 共识认知电池的日语版来探讨轻度认知障碍和轻度阿尔茨海默病患者多种认知功能的变化。
我们对 11 名轻度认知障碍（MCI）患者、11 名阿尔茨海默病患者和 27 名健康对照者进行了 MATRICS 共识认知电池日语版的测试。所有 MATRICS 共识认知电池日语版的领域得分均使用样本平均值和标准差转换为 t 分数，并对健康对照组、MCI 组和轻度阿尔茨海默病组之间的显著表现差异进行了比较。
与健康对照组相比，MCI 患者和轻度阿尔茨海默病患者的处理速度、言语学习和视觉学习方面的损伤程度相同。推理和解决问题能力仅在轻度阿尔茨海默病患者中出现显著损伤。工作记忆中的言语和视觉能力在 MCI 和轻度阿尔茨海默病组中表现出不同的表现，阿尔茨海默病组在这些领域的缺陷更为明显。注意力/警觉性和社会认知方面，三组间无显著差异。
MATRICS 共识认知电池日语版可用于阐明临床实践中正常衰老、MCI 和轻度痴呆认知功能障碍的特征。
