Huang Lieyan, Nie Lixing, Dai Zhong, Dong Jing, Jia Xiaofei, Yang Xuexin, Yao Lingwen, Ma Shuang-Cheng
National Institutes for Food and Drug Control, National Medical Products Administration, Beijing, 102629, China.
Shimadzu China Innovation Center, Beijing, 100020, China.
Chin Med. 2022 Mar 5;17(1):35. doi: 10.1186/s13020-022-00586-8.
Mass spectrometry imaging is a frontier technique which connects classical mass spectrometry with ion imaging. Various types of chemicals could be visualized in their native tissues using mass spectrometry imaging. Up to now, the most commonly applied mass spectrometry imaging techniques are matrix assisted laser desorption ionization mass spectrometry imaging, desorption electrospray ionization mass spectrometry imaging and secondary ion mass spectrometry imaging. This review gives an introduction to the principles, development and applications of commonly applied mass spectrometry imaging techniques, and then illustrates the application of mass spectrometry imaging in the investigation of traditional Chinese medicine. Recently, mass spectrometry imaging has been adopted to explore the spatial distribution of endogenous metabolites in traditional Chinese medicine. Data collected from mass spectrometry imaging can be further utilized to search for marker components of traditional Chinese medicine, discover new compounds from traditional herbs, and differentiate between medicinal plants that are similar in botanical features. Moreover, mass spectrometry imaging also plays a role in revealing the pharmacological and toxicological mechanisms of traditional Chinese medicine.
质谱成像技术是一种将经典质谱与离子成像相结合的前沿技术。利用质谱成像技术，可以在天然组织中可视化各种化学物质。目前，最常用的质谱成像技术是基质辅助激光解吸电离质谱成像、解吸电喷雾电离质谱成像和二次离子质谱成像。本文综述了常用质谱成像技术的原理、发展及应用，并阐述了质谱成像技术在中药研究中的应用。近年来，质谱成像技术已被用于探索中药中内源性代谢产物的空间分布。从质谱成像收集的数据可进一步用于寻找中药的标记成分、从传统草药中发现新化合物，以及区分植物特征相似的药用植物。此外，质谱成像在揭示中药的药理和毒理机制方面也发挥着作用。
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