Lin Lanying, Liao Guoyan, Chen Jinguang, Chen Xiang'en
Dermatology Department, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, China.
Dermatology Department, Taizhou Municipal Hospital, Taizhou, China.
Ann Palliat Med. 2022 Feb;11(2):743-755. doi: 10.21037/apm-22-70.
Acne is a chronic inflammatory disease that occurs in the sebaceous glands of the hair follicles. Depressed acne scars, also known as depressed scars, remain after recovery. Clinical treatments of depressed scars include chemical peels, surgical treatments, radio frequency treatments, and laser treatments. Ultra-pulse carbon dioxide (CO2) fractional laser treatment has become the main method for treating depressed scars in recent years, but there are no systematic reports on the effectiveness and safety of this treatment.
English databases, including PubMed, Embase, and Ovid-Medline, were searched to retrieve relevant articles. The search period ran from the establishment of the databases to April 2021. The search terms included CO2 lattice laser, depressed acne scars, depressed scars, and effectiveness.
A total of 6 articles comprising 467 patients with depressed acne scars were included in the meta-analysis. The results showed that patients treated with ultra-pulsed CO2 fractionated laser scored higher in skin smoothness compared to other methods [standard mean difference (SMD) =0.49, 95% confidence interval (CI): 0.13-0.84; P=0.008], and significantly higher total skin lesion scores (SMD =0.35, 95% CI: -0.00 to 0.70; P=0.05).
A total of 6 articles were included in this study on the clinical efficacy of the ultra-pulse CO2 fractional laser in the treatment of depressed acne scars. The study found that compared to other treatments, this laser had a better curative effect in terms of the effective rate and patient skin smoothness score.
痤疮是一种发生在毛囊皮脂腺的慢性炎症性疾病。痤疮凹陷性瘢痕，也称为凹陷性瘢痕，在恢复后依然存在。凹陷性瘢痕的临床治疗方法包括化学剥脱、手术治疗、射频治疗和激光治疗。超脉冲二氧化碳（CO2）分次激光治疗近年来已成为治疗凹陷性瘢痕的主要方法，但关于该治疗有效性和安全性的系统报道较少。
检索英文数据库，包括PubMed、Embase和Ovid-Medline，以检索相关文章。检索时间从数据库建立至2021年4月。检索词包括CO2点阵激光、痤疮凹陷性瘢痕、凹陷性瘢痕和有效性。
共有6篇文章纳入了467例痤疮凹陷性瘢痕患者的荟萃分析。结果显示，与其他方法相比，接受超脉冲CO2分次激光治疗的患者皮肤光滑度评分更高[标准均数差（SMD）=0.49，95%置信区间（CI）：0.13 - 0.84；P = 0.008]，且总皮肤病变评分显著更高（SMD = 0.35，95% CI：-0.00至0.70；P = 0.05）。
本研究共纳入6篇关于超脉冲CO2分次激光治疗痤疮凹陷性瘢痕临床疗效的文章。研究发现，与其他治疗方法相比，该激光在有效率和患者皮肤光滑度评分方面疗效更佳。
