Yan Hongtao, Sun Yan, Hu Yayu, Wu Youjun
Department of Dermatology, Taizhou Municipal Hospital, Taizhou, China.
Department of Public Security Supervision, Taizhou Municipal Hospital, Taizhou, China.
Int Wound J. 2023 Oct 9;21(2). doi: 10.1111/iwj.14429.
A meta-analysis was performed to investigate the efficacy of ultrapulse carbon dioxide dot matrix laser treatment for patients with facial scars. PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, China Biomedical Literature Database, and Wanfang Database were systematically searched for randomised controlled trials (RCTs) investigating ultrapulse carbon dioxide dot matrix laser treatment for facial scars, and the search was conducted from the time of database inception to July 2023. The retrieved literature was screened independently by two researchers, and data extraction and quality assessments were performed. The meta-analysis was conducted using RevMan 5.4 software. Outcome metrics included overall treatment effectiveness, complication rate, and Echelle d'évaluation clinique des cicatrices d'acné (ECCA) scores. Seventeen RCTs comprising 3703 patients were included, with 1853 patients in the experimental group and 1850 in the control group. The results showed that the experimental group had significantly increased overall treatment efficacy rates (odds ratio [OR]: 3.84, 95% confidence interval [CI]: 3.02-4.90, p < 0.001), reduced complication rates (OR: 0.35, 95% CI: 0.27-0.44, p < 0.001), and improved ECCA scores (standardised mean difference: -1.79, 95% CI: -2.53 to -1.05, p < 0.001) compared with the control group. In conclusion, as the primary treatment modality for facial acne depression scars, ultrapulse carbon dioxide dot matrix laser can significantly increase the overall treatment efficacy rate and ECCA scores and reduce the incidence of complications; however, higher-quality studies are needed for further validation.
进行了一项荟萃分析，以研究超脉冲二氧化碳点阵激光治疗面部瘢痕患者的疗效。系统检索了PubMed、EMBASE、Cochrane图书馆、中国知网、中国生物医学文献数据库和万方数据库，以查找研究超脉冲二氧化碳点阵激光治疗面部瘢痕的随机对照试验（RCT），检索时间从数据库建立至2023年7月。由两名研究人员独立筛选检索到的文献，并进行数据提取和质量评估。使用RevMan 5.4软件进行荟萃分析。结局指标包括总体治疗效果、并发症发生率和痤疮瘢痕临床评估量表（ECCA）评分。纳入了17项RCT，共3703例患者，其中试验组1853例，对照组1850例。结果显示，与对照组相比，试验组的总体治疗有效率显著提高（比值比[OR]：3.84，95%置信区间[CI]：3.02 - 4.90，p < 0.001），并发症发生率降低（OR：0.35，95% CI：0.27 - 0.44，p < 0.001），ECCA评分改善（标准化均数差：-1.79，95% CI：-2.53至-1.05，p < 0.001）。总之，作为面部痤疮凹陷性瘢痕的主要治疗方式，超脉冲二氧化碳点阵激光可显著提高总体治疗有效率和ECCA评分，并降低并发症发生率；然而，需要更高质量的研究进行进一步验证。
