Souid Imen, Korchef Atef, Souid Safouan
Campus for Girls Study, Pre-Medical Department, College of Sciences, King Khalid University, Box 3340, Abha, Saudi Arabia.
Central Analytical Laboratory of Animal Feeds, Box 155, Chotrana 1, 2036 Soukra, Tunisia.
Saudi Pharm J. 2022 May;30(5):570-584. doi: 10.1016/j.jsps.2022.02.014. Epub 2022 Feb 25.
The rapid transmission of the pneumonia (COVID-19) emerged as an entire worldwide health concern and it was declared as pandemic by the World Health Organization (WHO) as a consequence of the increasing reported infections number. COVID-19 disease is caused by the novel SARS-CoV-2 virus, and unfortunatly no drugs are currently approved against this desease. Accordingly, it is of outmost importance to review the possible therapeutic effects of naturally-occuring compounds that showed approved antiviral activities. The molecular docking approach offers a rapid prediction of a possible inhibition of the main enzymes M and RdRp that play crucial role in the SARS-CoV-2 replication and transcription. In the present work, we review the anti-viral activities of polyphenol compounds (phenolic acids, flavonoids and stilbene) derived from the traditional Chinese medicinal Recent molecular docking studies reported the possible binding of these polyphenols on SARS-CoV-2 enzymes M and RdRp active sites and showed interesting inhibitory effects. This antiviral activity was explained by the structure-activity relationships of the studied compounds. Also, pharmacokinetic analysis of the studied molecules is simulated in the present work. Among the studied polyphenol compounds, only five, namely caffeic acid, ferulic acid, quercetin, naringenin and catechin have drug-likeness characteristics. These five polyphenols derived from are promising drug candidates for the COVID-19 treatment.
肺炎（COVID-19）的快速传播已成为全球范围内的健康问题，由于报告的感染病例数不断增加，世界卫生组织（WHO）宣布其为大流行病。COVID-19疾病由新型SARS-CoV-2病毒引起，不幸的是，目前尚无针对该疾病的获批药物。因此，审查具有已获批抗病毒活性的天然化合物的潜在治疗效果至关重要。分子对接方法可快速预测可能对在SARS-CoV-2复制和转录中起关键作用的主要酶M和RdRp的抑制作用。在本研究中，我们综述了源自传统中药的多酚化合物（酚酸、黄酮类和芪类）的抗病毒活性。最近的分子对接研究报道了这些多酚与SARS-CoV-2酶M和RdRp活性位点的可能结合，并显示出有趣的抑制作用。这种抗病毒活性通过所研究化合物的构效关系来解释。此外，本研究还模拟了所研究分子的药代动力学分析。在所研究的多酚化合物中，只有咖啡酸、阿魏酸、槲皮素、柚皮素和儿茶素这五种具有类药特性。这些源自传统中药的五种多酚有望成为治疗COVID-19的候选药物。
