Ho Wan-Yi, Shen Zi-Han, Chen Yijing, Chen Ting-Hsu, Lu XiaoLin, Fu Yaw-Syan
Department of Anatomy, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Clinical Medicine, Xiamen Medical College, Xiamen, 361023, Fujian, China.
Heliyon. 2024 Apr 30;10(9):e30080. doi: 10.1016/j.heliyon.2024.e30080. eCollection 2024 May 15.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel human coronavirus, which has triggered a global pandemic of the coronavirus infectious disease 2019 (COVID-19). Outbreaks of emerging infectious diseases continue to challenge human health worldwide. The virus conquers human cells through the angiotensin-converting enzyme 2 receptor-driven pathway by mostly targeting the human respiratory tract. Quercetin is a natural flavonoid widely represented in the plant kingdom. Cumulative evidence has demonstrated that quercetin and its derivatives have various pharmacological properties including anti-cancer, anti-hypertension, anti-hyperlipidemia, anti-hyperglycemia, anti-microbial, antiviral, neuroprotective, and cardio-protective effects, because it is a potential treatment for severe inflammation and acute respiratory distress syndrome. Furthermore, it is the main life-threatening condition in patients with COVID-19. This article provides a comprehensive review of the primary literature on the predictable effectiveness of quercetin and its derivatives docked to multi-target of SARS-CoV-2 and host cells via and some of validation through , , and clinically to fight SARS-CoV-2 infections, contribute to the reduction of inflammation, which suggests the preventive and therapeutic latency of quercetin and its derived-products against COVID-19 pandemic, multisystem inflammatory syndromes (MIS), and long-COVID.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是一种新型人类冠状病毒，它引发了2019冠状病毒病（COVID-19）的全球大流行。新发传染病的爆发继续在全球范围内挑战人类健康。该病毒主要通过靶向人类呼吸道，通过血管紧张素转换酶2受体驱动的途径攻克人类细胞。槲皮素是一种在植物界广泛存在的天然黄酮类化合物。越来越多的证据表明，槲皮素及其衍生物具有多种药理特性，包括抗癌、抗高血压、抗高血脂、抗高血糖、抗微生物、抗病毒、神经保护和心脏保护作用，因为它是治疗严重炎症和急性呼吸窘迫综合征的潜在药物。此外，它是COVID-19患者主要的危及生命的病症。本文全面综述了关于槲皮素及其衍生物通过与SARS-CoV-2和宿主细胞的多靶点对接的可预测有效性的主要文献，以及通过……、……和临床验证以对抗SARS-CoV-2感染、减轻炎症的一些内容，这表明槲皮素及其衍生产品对COVID-19大流行、多系统炎症综合征（MIS）和新冠后遗症具有预防和治疗潜力。
