Lu Li, Xiong Yuan, Lin Ze, Chu Xiangyu, Panayi Adriana C, Hu Yiqiang, Zhou Juan, Mi Bobin, Liu Guohui
Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan, China.
Front Pharmacol. 2022 Oct 4;13:1009550. doi: 10.3389/fphar.2022.1009550. eCollection 2022.
Extensive research has implicated inflammation and oxidative stress in the development of multiple diseases, such as diabetes, hepatitis, and arthritis. Kinsenoside (KD), a bioactive glycoside component extracted from the medicinal plant , has been shown to exhibit potent anti-inflammatory and anti-oxidative abilities. In this review, we summarize multiple effects of KD, including hepatoprotection, pro-osteogenesis, anti-hyperglycemia, vascular protection, immune regulation, vision protection, and infection inhibition, which are partly responsible for suppressing inflammation signaling and oxidative stress. The protective action of KD against dysfunctional lipid metabolism is also associated with limiting inflammatory signals, due to the crosstalk between inflammation and lipid metabolism. Ferroptosis, a process involved in both inflammation and oxidative damage, is potentially regulated by KD. In addition, we discuss the physicochemical properties and pharmacokinetic profiles of KD. Advances in cultivation and artificial synthesis techniques are promising evidence that the shortage in raw materials required for KD production can be overcome. In addition, novel drug delivery systems can improve the rapid clearance and poor bioavailability of KD. In this integrated review, we aim to offer novel insights into the molecular mechanisms underlying the therapeutic role of KD and lay solid foundations for the utilization of KD in clinical practice.
广泛的研究表明，炎症和氧化应激与多种疾病的发生发展有关，如糖尿病、肝炎和关节炎。人参皂苷（KD）是从药用植物中提取的一种生物活性糖苷成分，已被证明具有强大的抗炎和抗氧化能力。在这篇综述中，我们总结了KD的多种作用，包括肝脏保护、促进骨生成、抗高血糖、血管保护、免疫调节、视力保护和感染抑制，这些作用部分归因于抑制炎症信号和氧化应激。由于炎症与脂质代谢之间的相互作用，KD对脂质代谢功能障碍的保护作用也与限制炎症信号有关。铁死亡是一个涉及炎症和氧化损伤的过程，可能受KD调控。此外，我们还讨论了KD的理化性质和药代动力学特征。种植和人工合成技术的进步为克服KD生产所需原材料短缺提供了有力证据。此外，新型药物递送系统可以改善KD快速清除和生物利用度差的问题。在这篇综合综述中，我们旨在为KD治疗作用的分子机制提供新的见解，并为KD在临床实践中的应用奠定坚实基础。
