Teta M J, Del Po M C, Kasl S V, Meigs J W, Myers M H, Mulvihill J J
J Chronic Dis. 1986;39(9):751-9. doi: 10.1016/0021-9681(86)90158-x.
A Connecticut Addendum to a multi-center National Cancer Institute study was developed to investigate psychosocial effects of long-term childhood and adolescent cancer survival. Cases (450), drawn from the files of the Connecticut Tumor Registry and 587 of their siblings were located and interviewed. Overall response rate was 84%. The frequency of lifetime major depression in survivors (males, 15%; females, 22%) did not appear to differ from that of their siblings (males, 12%; females, 24%) and was similar to those reported in the literature for the general population. The usual correlates of depression (sex, marital status, perception of health) were observed, independent of a history of a childhood malignancy. There were no differences in the reported frequencies of suicide attempts, running away or psychiatric hospitalizations for either sex. Eighty percent of the male survivors were rejected from the armed forces, 13% from college and 32% from employment. These values were significantly higher than those of the male siblings. Female survivors were significantly more likely than their sisters to be denied entrance into the military (p less than 0.05), but no differences were observed between females with respect to college or employment. Both sexes had more difficulty obtaining health and life insurance than their siblings (p less than 0.0001). Although survivors of childhood and adolescent cancer do not seem to be at excess risk for major depression, they do appear to have difficulty attaining certain major socioeconomic goals.
美国国立癌症研究所开展了一项多中心研究，在此基础上形成了康涅狄格州的一份附录，旨在调查儿童期和青少年期癌症长期存活者的心理社会影响。从康涅狄格肿瘤登记处的档案中选取了450例病例及其587名兄弟姐妹，并对他们进行了访谈。总体回应率为84%。存活者中终生患重度抑郁症的频率（男性为15%，女性为22%）似乎与他们的兄弟姐妹（男性为12%，女性为24%）没有差异，并且与文献中报道的普通人群的频率相似。观察到抑郁症的常见相关因素（性别、婚姻状况、健康认知），且与儿童期恶性肿瘤病史无关。无论男女，报告的自杀未遂、离家出走或住院治疗的频率均无差异。80%的男性存活者被武装部队拒绝，13%被大学拒绝，32%被拒绝就业。这些数值显著高于男性兄弟姐妹。女性存活者比她们的姐妹更有可能被拒绝入伍（p<0.05），但在女性进入大学或就业方面未观察到差异。与他们的兄弟姐妹相比，两性在获得健康保险和人寿保险方面都更困难（p<0.0001）。虽然儿童期和青少年期癌症的存活者似乎没有患重度抑郁症的额外风险，但他们在实现某些主要社会经济目标方面确实似乎存在困难。
