Wolf Peter, Krutmann Jean
Universitätsklinik für Dermatologie und Venerologie, Medizinische Universität Graz, Auenbruggerplatz 8, 8036, Graz, Österreich.
IUF - Leibniz-Institut für umweltmedizinische Forschung GmbH, Auf'm Hennekamp 50, 40225, Düsseldorf, Deutschland.
Hautarzt. 2022 Apr;73(4):257-265. doi: 10.1007/s00105-022-04959-w. Epub 2022 Mar 8.
Sunscreens provide excellent protection against erythema and against chronic damage such as photoaging and skin cancer. Today's challenges concern safety of the products and improved methods for standardizing the evaluation of their efficacy. Other important topics are the further development of sunscreen products, as well as personalization of use. Personalized sun protection based on the phenotype, the genetic profiles and moreover the skin's microbiome - all linked to the identification of certain consumer susceptibility factors - is an exciting new area of research. In particular, the expansion with innovative topical agents such as DNA repair liposomes in improved galenic formulations with UV filters tailored to the skin phototype and new topical antioxidants could in future provide even more comprehensive sun protection. New antioxidants and other agents such as nicotinamide could increase systemic photoprevention. Sustainability will also be an important aspect to protect consumers, but also the environment (i.e. especially marine wildlife) from toxic effects of sunscreens.
防晒霜能有效抵御红斑以及光老化和皮肤癌等慢性损伤。如今面临的挑战涉及产品安全性以及改进其功效评估的标准化方法。其他重要话题包括防晒产品的进一步研发以及个性化使用。基于表型、基因图谱以及皮肤微生物群的个性化防晒——所有这些都与某些消费者易感性因素的识别相关——是一个令人兴奋的新研究领域。特别是，通过在改进的药剂配方中添加创新的局部用药，如DNA修复脂质体，并搭配适合皮肤光型的紫外线滤过剂以及新型局部抗氧化剂，未来可能会提供更全面的防晒保护。新型抗氧化剂和烟酰胺等其他药剂可以增强全身光预防作用。可持续性也是一个重要方面，既能保护消费者，又能保护环境（尤其是海洋野生动物）免受防晒霜的毒性影响。
