Department of Emergency, Hospital Nacional Arzobispo Loayza, Cercado de Lima, Lima, Peru.
Facultad de Medicina, Universidad Peruana Cayetano Heredia, San Martín de Porres, Lima, Peru.
PLoS One. 2022 Mar 8;17(3):e0265089. doi: 10.1371/journal.pone.0265089. eCollection 2022.
Peru is the country with the world's highest COVID-19 death rate per capita. Characteristics associated with increased mortality among adult patients with COVID-19 pneumonia in this setting are not well described.
Retrospective, single-center cohort study including 1537 adult patients hospitalized with a diagnosis of SARS-CoV-2 pneumonia between May 2020 and August 2020 at a national hospital in Lima, Peru. The primary outcome measure was in-hospital mortality.
In-hospital mortality was 49.71%. The mean age was 60 ± 14.25 years, and 68.38% were males. We found an association between mortality and inflammatory markers, mainly leukocytes, D-dimer, lactate dehydrogenase, C-reactive protein and ferritin. A multivariate model adjusted for age, hypertension, diabetes mellitus, and corticosteroid use demonstrated that in-hospital mortality was associated with greater age (RR: 2.01, 95%CI: 1.59-2.52) and a higher level of oxygen requirement (RR: 2.77, 95%CI: 2.13-3.62). Conclusions: In-hospital mortality among COVID-19 patients in Peru is high and is associated with greater age and higher oxygen requirements.
秘鲁是全球 COVID-19 死亡率最高的国家。在这一背景下，与成人 COVID-19 肺炎患者死亡率增加相关的特征尚未得到很好的描述。
这是一项回顾性、单中心队列研究，纳入了 2020 年 5 月至 8 月期间在秘鲁利马的一家国家医院因 SARS-CoV-2 肺炎住院的 1537 名成年患者。主要结局指标是住院死亡率。
住院死亡率为 49.71%。平均年龄为 60 ± 14.25 岁，68.38%为男性。我们发现死亡率与炎症标志物有关，主要是白细胞、D-二聚体、乳酸脱氢酶、C-反应蛋白和铁蛋白。多变量模型调整了年龄、高血压、糖尿病和皮质类固醇的使用，表明住院死亡率与年龄较大（RR：2.01，95%CI：1.59-2.52）和更高的氧气需求水平（RR：2.77，95%CI：2.13-3.62）相关。
秘鲁 COVID-19 患者的住院死亡率较高，与年龄较大和更高的氧气需求相关。
