秘鲁住院成人 COVID-19 肺炎患者死亡率高：一项单中心回顾性队列研究。
High mortality among hospitalized adult patients with COVID-19 pneumonia in Peru: A single centre retrospective cohort study.
机构信息
Department of Emergency, Hospital Nacional Arzobispo Loayza, Cercado de Lima, Lima, Peru.
Facultad de Medicina, Universidad Peruana Cayetano Heredia, San Martín de Porres, Lima, Peru.
出版信息
PLoS One. 2022 Mar 8;17(3):e0265089. doi: 10.1371/journal.pone.0265089. eCollection 2022.
BACKGROUND
Peru is the country with the world's highest COVID-19 death rate per capita. Characteristics associated with increased mortality among adult patients with COVID-19 pneumonia in this setting are not well described.
METHODS
Retrospective, single-center cohort study including 1537 adult patients hospitalized with a diagnosis of SARS-CoV-2 pneumonia between May 2020 and August 2020 at a national hospital in Lima, Peru. The primary outcome measure was in-hospital mortality.
RESULTS
In-hospital mortality was 49.71%. The mean age was 60 ± 14.25 years, and 68.38% were males. We found an association between mortality and inflammatory markers, mainly leukocytes, D-dimer, lactate dehydrogenase, C-reactive protein and ferritin. A multivariate model adjusted for age, hypertension, diabetes mellitus, and corticosteroid use demonstrated that in-hospital mortality was associated with greater age (RR: 2.01, 95%CI: 1.59-2.52) and a higher level of oxygen requirement (RR: 2.77, 95%CI: 2.13-3.62). Conclusions: In-hospital mortality among COVID-19 patients in Peru is high and is associated with greater age and higher oxygen requirements.
背景
秘鲁是全球 COVID-19 死亡率最高的国家。在这一背景下，与成人 COVID-19 肺炎患者死亡率增加相关的特征尚未得到很好的描述。
方法
这是一项回顾性、单中心队列研究，纳入了 2020 年 5 月至 8 月期间在秘鲁利马的一家国家医院因 SARS-CoV-2 肺炎住院的 1537 名成年患者。主要结局指标是住院死亡率。
结果
住院死亡率为 49.71%。平均年龄为 60 ± 14.25 岁，68.38%为男性。我们发现死亡率与炎症标志物有关，主要是白细胞、D-二聚体、乳酸脱氢酶、C-反应蛋白和铁蛋白。多变量模型调整了年龄、高血压、糖尿病和皮质类固醇的使用，表明住院死亡率与年龄较大（RR：2.01，95%CI：1.59-2.52）和更高的氧气需求水平（RR：2.77，95%CI：2.13-3.62）相关。
结论
秘鲁 COVID-19 患者的住院死亡率较高，与年龄较大和更高的氧气需求相关。
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