Faculty of Chemistry, Adam Mickiewicz University, Uniwersytetu Poznanskiego 8, 61-614 Poznan, Poland.
Nat Prod Rep. 2022 Sep 21;39(9):1678-1704. doi: 10.1039/d2np00004k.
Covering: 2011 to 2021The structural division of ansamycins, including those of atypical cores and different lengths of the ansa chains, is presented. Recently discovered benzenoid and atypical ansamycin scaffolds are presented in relation to their natural source and biosynthetic routes realized in bacteria as well as their muta and semisynthetic modifications influencing biological properties. To better understand the structure-activity relationships among benzenoid ansamycins structural aspects together with mechanisms of action regarding different targets in cells, are discussed. The most promising directions for structural optimizations of benzenoid ansamycins, characterized by predominant anticancer properties, were discussed in view of their potential medical and pharmaceutical applications. The bibliography of the review covers mainly years from 2011 to 2021.
2011 年至 2021 年
本文介绍了 ansamycins 的结构分类，包括具有非典型核心和ansa 链不同长度的 ansamycins。本文还介绍了最近发现的苯并型和非典型 ansamycin 支架，涉及它们的天然来源和在细菌中实现的生物合成途径，以及影响生物特性的突变和半合成修饰。为了更好地理解苯并型 ansamycins 之间的结构-活性关系，本文讨论了与细胞中不同靶点相关的结构方面和作用机制。本文还讨论了具有主要抗癌特性的苯并型 ansamycins 的结构优化最有前景的方向，考虑到它们在医学和药物方面的潜在应用。本文的参考文献主要涵盖了 2011 年至 2021 年的年份。
