Graduate Program in Health Promotion, University of Santa Cruz do Sul (UNISC), Independência Av, 2293 - Universitário, Santa Cruz Do Sul, RS, 96815-900, Brazil.
Faculty of Education, Arts and Sport, Westerm Norway University of Applied Sciences, Songdal, Norway.
BMC Cardiovasc Disord. 2022 Mar 9;22(1):92. doi: 10.1186/s12872-022-02537-5.
Genetic factors along with inadequate lifestyle habits are associated with the development of cardiometabolic alterations. Thus, the present study aimed to examine the role of sedentary behavior on the relationship between rs9939609 polymorphism (fat mass and obesity-associated gene-FTO) and cardiometabolic risk score according to cardiorespiratory fitness (CRF) levels in children and adolescents.
A cross-sectional study with 1215 children and adolescents (692 girls), aged between 6 and 17 years. Screen time as a marker of sedentary behavior was evaluated through a self-reported questionnaire and CRF was estimated using the 6-min walking and running test. The genotyping of the FTO rs9939609 polymorphism was performed using a real-time polymerase chain reaction. Clustered cardiometabolic risk score (cMetS) was calculated by summing z-scores of total cholesterol/high-density lipoprotein cholesterol ratio, triglycerides, glucose, systolic blood pressure, and waist circumference, and dividing it by five. Moderation analyses were tested using multiple linear regression models.
The coefficient of the interaction term of FTO (rs9939609) and screen time indicated that screen time was a significant moderator on the relationship between FTO rs9939609 polymorphism and cMetS (p = 0.047) in children and adolescents classified with low CRF (β = 0.001; 95% CI = 0.001; 0.002). It was observed a significant association between genotype risk (AA) of FTO polymorphism and cMetS, in participants that spent more than 378 min a day in front of screen-based devices (β = 0.203; 95% CI = 0.000; 0.405). No interaction term was found for those with high CRF.
High sedentary behavior seems to influence the relationship between genetic predisposition to obesity and cardiometabolic risk factors in children and adolescents with low CRF.
遗传因素和不良的生活方式习惯与心脏代谢改变的发展有关。因此，本研究旨在探讨久坐行为在 rs9939609 多态性（脂肪量和肥胖相关基因-FTO）与心脏代谢风险评分之间关系中的作用，以及根据儿童和青少年的心肺功能（CRF）水平。
横断面研究纳入了 1215 名 6 至 17 岁的儿童和青少年（692 名女孩）。通过自我报告问卷评估久坐行为的屏幕时间，使用 6 分钟步行和跑步测试估计 CRF。使用实时聚合酶链反应进行 FTO rs9939609 多态性的基因分型。通过将总胆固醇/高密度脂蛋白胆固醇比值、甘油三酯、葡萄糖、收缩压和腰围的 z 分数相加并除以 5 来计算聚类心脏代谢风险评分（cMetS）。使用多线性回归模型测试调节分析。
FTO（rs9939609）和屏幕时间的交互项系数表明，在 CRF 较低的儿童和青少年中，屏幕时间是 FTO rs9939609 多态性与 cMetS 之间关系的一个显著调节因素（p=0.047）（β=0.001；95%CI=0.001；0.002）。在每天花超过 378 分钟在屏幕设备前的参与者中，FTO 多态性的基因型风险（AA）与 cMetS 之间存在显著相关性（β=0.203；95%CI=0.000；0.405）。对于那些 CRF 较高的人，没有发现交互项。
在 CRF 较低的儿童和青少年中，高久坐行为似乎会影响肥胖遗传易感性与心脏代谢危险因素之间的关系。
