Engineering Systems Design, Department of Technology Management and Economics, Technical University of Denmark, Kongens Lyngby, Denmark
Engineering Systems Design, Department of Technology Management and Economics, Technical University of Denmark, Kongens Lyngby, Denmark.
BMJ Open. 2022 Mar 9;12(3):e051109. doi: 10.1136/bmjopen-2021-051109.
A growing body of evidence suggests that hearing loss is a significant and potentially modifiable risk factor for cognitive impairment. Although the mechanisms underlying the associations between cognitive decline and hearing loss are unclear, listening effort has been posited as one of the mechanisms involved with cognitive decline in older age. To date, there has been a lack of research investigating this association, particularly among adults with mild cognitive impairment (MCI).
15-25 cognitively healthy participants and 15-25 patients with MCI (age 40-85 years) will be recruited to participate in an exploratory study investigating the association between cognitive functioning and listening effort. Both behavioural and objective measures of listening effort will be investigated. The sentence-final word identification and recall (SWIR) test will be administered with single talker non-intelligible speech background noise while monitoring pupil dilation. Evaluation of cognitive function will be carried out in a clinical setting using a battery of neuropsychological tests. This study is considered exploratory and proof of concept, with information taken to help decide the validity of larger-scale trials.
Written approval exemption was obtained by the Scientific Ethics Committee in the central region of Denmark (De Videnskabsetiske Komiteer i Region Hovedstaden), reference 19042404, and the project is registered pre-results at clinicaltrials.gov, reference NCT04593290, Protocol ID 19042404. Study results will be disseminated in peer-reviewed journals and conferences.
越来越多的证据表明，听力损失是认知障碍的一个重要且潜在可改变的危险因素。尽管认知能力下降与听力损失之间的关联机制尚不清楚，但听力努力已被认为是导致老年认知能力下降的机制之一。迄今为止，还缺乏研究调查这种关联，特别是在轻度认知障碍（MCI）的成年人中。
将招募 15-25 名认知健康的参与者和 15-25 名 MCI 患者（年龄 40-85 岁）参与一项探索性研究，调查认知功能与听力努力之间的关联。将研究行为和客观的听力努力测量。将在有单说话者的不可理解的言语背景噪声的情况下进行句子结尾词识别和回忆（SWIR）测试，同时监测瞳孔扩张。在临床环境中使用神经心理学测试套件评估认知功能。这项研究被认为是探索性和概念验证性的，旨在获取信息以帮助确定更大规模试验的有效性。
丹麦中心地区科学伦理委员会（De Videnskabsetiske Komiteer i Region Hovedstaden）已豁免书面批准，注册号为 19042404，该项目已在 clinicaltrials.gov 上预先注册，注册号为 NCT04593290，方案 ID 为 19042404。研究结果将在同行评议的期刊和会议上发表。
