Li Wei, Yue Ling, Xiao Shifu
Department of Geriatric Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Geriatric Psychiatry, Alzheimer's Disease and Related Disorders Center, Shanghai Jiao Tong University, Shanghai, China.
Front Nutr. 2022 Feb 21;9:752833. doi: 10.3389/fnut.2022.752833. eCollection 2022.
Previous studies show that the consumption of tea is associated with several beneficial outcomes for brain health, but there is little data among the elderly in China.
The objective was to explore the longitudinal relationship between tea consumption and the risk of cognitive decline.
The current data was obtained from the China Longitudinal Aging Study (CLAS), and a total of 3,246 residents aged 60 years and above were recruited in this study. Some of them ( = 111) underwent a standard T1-weighted magnetic resonance imaging (MRI), from which the volumes of the corpus callosum (CC) and hippocampus were calculated, and detailed tea consumption information was obtained through a standardized questionnaire at baseline. The cognitive diagnosis of each participant was made by attending psychiatrists at baseline and follow-up. Their overall cognitive function was assessed by the Montreal Cognitive Assessment (MoCA), while their associative learning ability was assessed by an associative learning test (ALT). Finally, 1,545 elderly with normal cognitive function completed the baseline and follow-up assessment and were included in the final study.
After controlling gender, education, smoking, take exercise and hobbies, we found that the elderly with tea consumption habits had a lower incidence rate of cognitive decline ( = 0.002, OR = 0.604, 95%CI:0.437~0.836) and tea consumption was negatively correlated with the change scores of MoCA (r = -0.056, = 0.029). What's more, the CC_posterior volume of tea drinkers was significantly smaller than that of non-tea drinkers, while the baseline ALT score of tea drinkers was significantly higher than that of non-tea drinkers. The results of correlation analysis showed that the CC_posterior volume was significantly correlated with ALT change score (r = -0.319, = 0.010).
The habit of tea consumption is associated with less incidence of cognitive impairment among the Chinese elderly, and it may prevent a decline in memory and associative learning by affecting the volume of the posterior corpus callosum.
先前的研究表明，饮茶与对大脑健康的多种有益结果相关，但在中国老年人中相关数据较少。
探讨饮茶与认知能力下降风险之间的纵向关系。
当前数据来自中国老年纵向研究（CLAS），本研究共招募了3246名60岁及以上的居民。其中部分人（n = 111）接受了标准的T1加权磁共振成像（MRI），据此计算胼胝体（CC）和海马体的体积，并通过基线时的标准化问卷获取详细的饮茶信息。每位参与者的认知诊断由精神科医生在基线和随访时进行。通过蒙特利尔认知评估（MoCA）评估他们的整体认知功能，同时通过联想学习测试（ALT）评估他们的联想学习能力。最后，1545名认知功能正常的老年人完成了基线和随访评估并被纳入最终研究。
在控制性别、教育程度、吸烟、锻炼和爱好后，我们发现有饮茶习惯的老年人认知能力下降的发生率较低（P = 0.002，OR = 0.604，95%CI：0.437~0.836），且饮茶与MoCA的变化得分呈负相关（r = -0.056，P = 0.029）。此外，饮茶者的CC后体体积显著小于非饮茶者，而饮茶者的基线ALT得分显著高于非饮茶者。相关分析结果显示，CC后体体积与ALT变化得分显著相关（r = -0.319，P = 0.010）。
饮茶习惯与中国老年人认知障碍发生率较低相关，且可能通过影响胼胝体后体体积来预防记忆和联想学习能力的下降。
