Areekul S, Boonme Y
Southeast Asian J Trop Med Public Health. 1986 Mar;17(1):48-52.
Hydrogen peroxide (H2O2) has been incriminated to have an oxidative killing malaria parasite. As P. berghei-infected mouse red cells generated H2O2 in vivo, this would result in the alteration of catalase status of the host. The present study was undertaken to determine catalase activity in red cells and liver of mice infected with P. berghei. The studies were performed in 17 samples of infected red cells as well as 20 samples of the normal red cells. Results showed that the catalase activity in red cells of the infected group was significantly lower (p less than 0.01) than that of the normal group. There was a reverse relationship between catalase activity and parasitemia. Crude parasite lysates possessed no catalase activity. Liver catalase content in the infected group was also found to be significantly lower (p less than 0.05) than that of the control group. All these findings indicated that P. berghei-infected mice caused a depressed catalase activity in red cells and liver which was possibly due to the catalatic function in detoxifying the increased H2O2 to water and free oxygen.
过氧化氢（H2O2）被认为具有氧化杀灭疟原虫的作用。由于感染伯氏疟原虫的小鼠红细胞在体内会产生H2O2，这会导致宿主过氧化氢酶状态的改变。本研究旨在测定感染伯氏疟原虫的小鼠红细胞和肝脏中的过氧化氢酶活性。研究对17份感染红细胞样本以及20份正常红细胞样本进行。结果显示，感染组红细胞中的过氧化氢酶活性显著低于正常组（p小于0.01）。过氧化氢酶活性与疟原虫血症呈负相关。粗制的寄生虫裂解物不具有过氧化氢酶活性。还发现感染组肝脏中的过氧化氢酶含量也显著低于对照组（p小于0.05）。所有这些发现表明，感染伯氏疟原虫的小鼠红细胞和肝脏中的过氧化氢酶活性降低，这可能是由于过氧化氢酶将增加的H2O2解毒为水和游离氧的催化功能所致。
