Department of Clinical Pharmacology, Medical University of Lodz, Kopcińskiego 22, 90-153 Łódź, Poland.
Department of Haemostasis and Haemostatic Disorders, Medical University of Lodz, Mazowiecka 6/8, 92-235 Łódź, Poland.
Nutrients. 2022 Mar 4;14(5):1083. doi: 10.3390/nu14051083.
The aim of the study was to evaluate the relationship between polyphenol or polyunsaturated fatty acids (PUFAs) consumption and the selected metabolic and inflammatory markers in type 2 diabetes (T2DM) patients.
The study enrolled 129 diabetics (49 men, mean age 64.1 ± 9.8 years) with different amounts of polyphenol and PUFAs consumption.
A significant effect of polyphenol or PUFAs omega-3 consumption on fasting glucose concentration (FG) or glycated haemoglobin fraction (HbA1c) was reported. A negative association was observed between FG and total polyphenol, flavonoid, flavan-3-ol and stilbene intake. In the group with high flavonoid intake, the FG was significantly lower compared to the group characterised by low flavonoid intake. Polyphenols, except stilbenes, did not modulate HbA1c. Additionally, higher consumption of PUFAs omega-3 significantly decreased HbA1c, and the intake of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids negatively and significantly correlated with FG and HbA1c. Further analysis confirmed a significant association between EPA + DHA intake and HbA1c, with significant interactions with age and gender or with body mass index and waist-to-hip ratio. The dietary intake of polyphenols or PUFAs was independent of familial diabetes or diabetic diet application.
Our study indicates a positive effect of high consumption of flavonoids, omega-3 PUFAs and stilbenes on the markers of carbohydrate metabolism balance and the absence of such an effect on other cardiometabolic markers and inflammatory conditions.
本研究旨在评估多酚或多不饱和脂肪酸（PUFAs）的摄入量与 2 型糖尿病（T2DM）患者的某些代谢和炎症标志物之间的关系。
本研究纳入了 129 名不同多酚和 PUFAs 摄入量的糖尿病患者（49 名男性，平均年龄 64.1 ± 9.8 岁）。
报告了多酚或 PUFAs ω-3 摄入量对空腹血糖（FG）或糖化血红蛋白（HbA1c）的显著影响。多酚和 PUFAs ω-3 的摄入量与 FG 或糖化血红蛋白呈负相关。在黄酮类摄入量较高的组中，FG 显著低于黄酮类摄入量较低的组。除了白藜芦醇以外，多酚对 HbA1c 没有调节作用。此外，较高的 PUFAs ω-3 摄入量可显著降低 HbA1c，并且 EPA 和 DHA 酸的摄入量与 FG 和 HbA1c 呈负相关且显著。进一步的分析证实，EPA + DHA 摄入量与 HbA1c 之间存在显著的关联，与年龄和性别或体重指数和腰臀比之间存在显著的交互作用。多酚或 PUFAs 的饮食摄入量与家族性糖尿病或糖尿病饮食的应用无关。
我们的研究表明，高摄入量的类黄酮、ω-3 PUFAs 和白藜芦醇对碳水化合物代谢平衡的标志物具有积极影响，而对其他心血管代谢标志物和炎症状态则没有这种影响。
